The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Outcomes Among Hypertensive Patients With Concomitant Peripheral and Coronary Artery Disease: Findings From the INternational VErapamil-SR/Trandolapril STudy
Open accessAbstract
Hypertension is a common risk factor for peripheral arterial disease (PAD). Guidelines suggest treating PAD patients to a blood pressure <130/80 mm Hg; therefore, our objective was to explore whether attainment of this target blood pressure is associated with improved outcomes. We performed a post hoc analysis of the INternational VErapamil-SR/Trandolapril STudy, a randomized clinical trial, which included hypertensive patients with concomitant PAD and coronary artery disease. There were 2699 PAD patients followed for a mean of 2.7 years (60 970 patient-years). The primary outcome, all-cause death, nonfatal myocardial infarction, or nonfatal stroke, occurred in 16.3% of PAD patients versus 9.2% without PAD (adjusted hazard ratio: 1.26 [95% CI: 1.13 to 1.40]; P <0.0001). The primary outcome occurred least frequently among PAD patients treated to an average systolic blood pressure of 135 to 145 mm Hg and an average diastolic blood pressure of 60 to 90 mm Hg. PAD patients displayed a J-shape relationship with systolic blood pressure and the primary outcome, although individuals without PAD did not. PAD patients may require a different target blood pressure than those without PAD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Racial and ethnic disparities in revascularization for patients with PAD have been well documented since the 1990s.87,106”
From Racial and Ethnic Disparities in Peripheral Artery Disease (2021) · cites this paper as [87]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663
Antman, E. M., Anbe, D. T., Armstrong, P. W., Bates, E., Green, L. A., Hand, M. M., Hochman, J. S., Krumholz, H. M., Kushner, F. G., Lamas, G. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000134791.68010.fa · Cited by 8,348
Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events
Bhatt, D. L., Fox, K. A. A., Hacke, W., Berger, P. B., Black, H. R., Boden, W. E., Cacoub, P., Cohen, E. A., Creager, M. A., Easton, J. D., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa060989 · Cited by 2,819
Mortality over a Period of 10 Years in Patients with Peripheral Arterial Disease
Criqui, M. H., Langer, R. D., Fronek, A., Feigelson, H. S., Klauber, M. R., McCann, T. J., & Browner, D. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202063260605 · Cited by 2,579
Bhatt, D. L. (2006) · JAMA · doi:10.1001/jama.295.2.180 · Cited by 1,644
One-year cardiovascular event rates in outpatients with atherothrombosis
Steg, P. G., Bhatt, D. L., Wilson, P. W. F., D’Agostino, R., Ohman, E. M., Röther, J., Liau, C.-S., Hirsch, A. T., Mas, J.-L., Ikeda, Y., et al. (2007) · JAMA · doi:10.1001/jama.297.11.1197 · Cited by 1,382
Pepine, C. J., Handberg, E. M., Cooper‐DeHoff, R. M., Marks, R. G., Kowey, P. R., Messerli, F. H., Mancia, G., Cangiano, J. L., García-Barreto, D., Keltai, M., et al. (2003) · JAMA · doi:10.1001/jama.290.21.2805 · Cited by 1,278
Self-citationMesserli, F. H., Mancia, G., Conti, C. R., Hewkin, A. C., Kupfer, S., Champion, A., Kolloch, R. E., Bénétos, A., & Pepine, C. J. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-12-200606200-00005 · Cited by 777
Self-citationTreatment of Hypertension in the Prevention and Management of Ischemic Heart Disease
Rosendorff, C., Black, H. R., Cannon, C. P., Gersh, B. J., Gore, J. M., Izzo, J. L., Kaplan, N. M., O’Connor, C. M., O’Gara, P. T., & Oparil, S. (2007) · Circulation · doi:10.1161/circulationaha.107.183885 · Cited by 759
Use of ankle brachial pressure index to predict cardiovascular events and death: a cohort study
Leng, G. C., Fowkes, F. G. R., Alexander, L. E. E., Dunbar, J., Housley, E., & Ruckley, C. V. (1996) · BMJ · doi:10.1136/bmj.313.7070.1440 · Cited by 525
Farnett, L. (1991) · JAMA · doi:10.1001/jama.265.4.489 · Cited by 417
Patients with peripheral arterial disease in the CHARISMA trial
Cacoub, P., Bhatt, D. L., Steg, P. G., Topol, E. J., Creager, M. A., & for the CHARISMA Investigators (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn534 · Cited by 356
Impact of ramipril in patients with evidence of clinical or subclinical peripheral arterial disease
Östergren, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2003.10.033 · Cited by 324
Morbidity and mortality in hypertensive adults with a low ankle/arm blood pressure index
Newman, A. B. (1993) · JAMA · doi:10.1001/jama.270.4.487 · Cited by 300
Morbidity and Mortality in Hypertensive Adults With a Low Ankle/Arm Blood Pressure Index
Newman, A. B. (1993) · JAMA · doi:10.1001/jama.1993.03510040091035 · Cited by 257
Cacoub, P., Abola, M. T. B., Baumgärtner, I., Bhatt, D. L., Creager, M. A., Liau, C., Goto, S., Röther, J., Steg, P. G., & Hirsch, A. T. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.10.023 · Cited by 257
Long-Term Prognosis of Patients With Peripheral Arterial Disease
Welten, G. M. J. M., Schouten, O., Hoeks, S. E., Chonchol, M., Vidaković, R., van Domburg, R. T., Bax, J. J., van Sambeek, M. R. H. M., & Poldermans, D. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.077 · Cited by 230
Mackenzie, I. S., McEniery, C. M., Dhakam, Z., Brown, M. J., Cockcroft, J. R., & Wilkinson, I. B. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.133801 · Cited by 220
Eagle, K. A., Rihal, C. S., Foster, E. D., Mickel, M. C., & Gersh, B. J. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90596-7 · Cited by 216
Atherosclerotic Peripheral Vascular Disease Symposium II
Hiatt, W. R., Goldstone, J., Smith, S. C., McDermott, M. M., Moneta, G. L., Oka, R. K., Newman, A. B., Pearce, W. H., & for Writing Group 1 (2008) · Circulation · doi:10.1161/circulationaha.108.191171 · Cited by 173
Pepine, C. J., Handberg, E. M., Marks, R. G., Conlon, M., Cooper‐DeHoff, R. M., Volkers, P., & Zellig, P. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00423-9 · Cited by 145
Self-citationHirsch, A. T., Halverson, S. L., Treat‐Jacobson, D., Hotvedt, P. S., Lunzer, M. M., Krook, S. H., Rajala, S., & Hunninghake, D. B. (2001) · Vascular Medicine · doi:10.1177/1358836x0100600204 · Cited by 101
Beta blockers for peripheral arterial disease
Paravastu, S. C. V., Mendonca, D. A., & Silva, A. D. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005508.pub2 · Cited by 93
The J-Curve Phenomenon and the Treatment of Hypertension-Reply
Farnett, L. E. (1991) · JAMA · doi:10.1001/jama.1991.03470010068027 · Cited by 79
Medication Underuse During Long-Term Follow-Up in Patients With Peripheral Arterial Disease
Hoeks, S. E., Reimer, W. J. M. S. O., van Gestel, Y. R. B. M., Schouten, O., Lenzen, M. J., Flu, W., van Kuijk, J., Latour, C. H. M., Bax, J. J., van Urk, H., et al. (2009) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.109.868505 · Cited by 69
Beta Blockers for Peripheral Arterial Disease
Paravastu, S. C. V., Mendonça, D., & da Silva, A. (2009) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2009.02.019 · Cited by 66
Ried, L. D., Tueth, M. J., Handberg, E. M., & Nyanteh, H. (2006) · Quality of Life Research · doi:10.1007/s11136-005-3515-2 · Cited by 50
Self-citation
Research works printed but not linked: 1
- 10.1001/jama.1991.03460040065031 · DOI
Cited by
Sorted by citations
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000065 · Cited by 7,391
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000066 · Cited by 4,347
Aboyans, V., Ricco, J.-B., Bartelink, M.-L. E. L., Björck, M., Brodmann, M., Cohnert, T., Collet, J.-P., Czerny, M., De Carlo, M., Debus, S., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx095 · Cited by 3,293
Metadata
- Authors
- Bavry, A. A., Anderson, R. D., Gong, Y., Denardo, S. J., Cooper-DeHoff, R. M., Handberg, E. M., & Pepine, C. J.
- Affiliations
- University of Florida (US)
- From the Division of Cardiovascular Medicine, College of Medicine (A.A.B., R.D.A., S.J.D., R.M.C.-D., E.M.H., C.J.P.), and Department of Pharmacotherapy and Translational Research, College of Pharmacy (Y.G., R.M.C.-D.), University of Florida, Gainesville, Fla.
- ORCID
- Venue
- Hypertension
- Published
- 2010-01
- Volume
- 55
- Issue
- 1
- Pages
- 48-53
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3000120
- OpenAlex
- W2019678113
- Semantic Scholar
- 902882d2b6ece6b530f147192a35483f0cc6b00a
- Cited by
- 188
- References
- 31
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 15 · 2023: 16 · 2022: 10 · 2021: 22 · 2020: 14 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 7 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 10
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K23HL086558)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- peripheral arterial disease, coronary artery disease, blood pressure targets, systolic blood pressure, J-shaped relationship, cardiovascular outcomes, all-cause mortality, myocardial infarction, stroke, antihypertensive therapy
- MeSH terms
- Adrenergic beta-Antagonists, Aged, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Aspirin, Blood Pressure, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Hypertension, Male, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Peripheral Vascular Diseases, Outcome Assessment, Health Care, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Angiotensin II Type 1 Receptor Blockers, Kaplan-Meier Estimate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
