Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Open accessAbstract
Stiffening of conduit arteries is a risk factor for cardiovascular morbidity. Aortic wall stiffening increases pulsatile hemodynamic forces that are detrimental to the microcirculation in highly perfused organs, such as the heart, brain, and kidney. Arterial stiffness is associated with hypertension but presumed to be due to an adaptive response to increased hemodynamic load. In contrast, a recent clinical study found that stiffness precedes and may contribute to the development of hypertension although the mechanisms underlying hypertension are unknown. Here, we report that in a diet-induced model of obesity, arterial stiffness, measured in vivo, develops within 1 month of the initiation of the diet and precedes the development of hypertension by 5 months. Diet-induced obese mice recapitulate the metabolic syndrome and are characterized by inflammation in visceral fat and aorta. Normalization of the metabolic state by weight loss resulted in return of arterial stiffness and blood pressure to normal. Our findings support the hypothesis that arterial stiffness is a cause rather than a consequence of hypertension.
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Weight loss has a beneficial effect on blood pressure control.
“Clinical and animal studies have documented that weight gain can raise arterial pressure whereas weight loss has a beneficial effect on blood pressure control (9–11).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [11]
Weight gain can raise arterial pressure.
“Clinical and animal studies have documented that weight gain can raise arterial pressure whereas weight loss has a beneficial effect on blood pressure control (9–11).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [11]
Obesity-associated vascular changes can be reversed by weight loss even after their establishment.
“Importantly, obesity-associated vascular changes can be reversed by weight loss even after their establishment (11;69).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [11]
In obesity, vascular alterations precede hypertension.
“Consistent with the notion that in obesity vascular alterations precede hypertension, Weisbrod et al. (11) demonstrated that diet-induced obese mice develop arterial stiffness and endothelial dysfunction prior to the onset of hypertension.”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [11]
Diet-induced obese mice develop arterial stiffness and endothelial dysfunction prior to the onset of hypertension.
“Consistent with the notion that in obesity vascular alterations precede hypertension, Weisbrod et al. (11) demonstrated that diet-induced obese mice develop arterial stiffness and endothelial dysfunction prior to the onset of hypertension.”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [11]
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References 43 · Cited by 317
- Authors
- Weisbrod, R. M., Shiang, T., Al Sayah, L., Fry, J. L., Bajpai, S., Reinhart-King, C. A., Lob, H. E., Santhanam, L., Mitchell, G., Cohen, R. A., & Seta, F.
- Affiliations
- Boston University (US)
- From the Vascular Biology Section, Boston University School of Medicine, Boston, MA (R.M.W., T.S., L.A.S., J.L.F., R.A.C., F.S.); Biomedical Engineering (S.B., C.A.R.-K.) and Department of Biomedical Sciences, College of Veterinary Medicine (H.E.L.), Cornell University, Ithaca, NY; Department of Anesthesiology and Critical Care Medicine, John Hopkins University, Baltimore, MD (L.S.); and Cardiovascular Engineering, Inc, Norwood, MA (G.M.).
- ORCID
- Venue
- Hypertension
- Published
- 2013-12
- Volume
- 62
- Issue
- 6
- Pages
- 1105-1110
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3951434
- OpenAlex
- W2131207264
- Cited by
- 317
- References
- 43
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 24 · 2023: 19 · 2022: 21 · 2021: 36 · 2020: 29 · 2019: 23 · 2018: 24 · 2017: 31 · 2016: 33 · 2015: 29 · 2014: 27 · 2013: 3
- FWCI
- 20.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL105287, R21HL097296, T32HL007224, HHSN268201000031C, HL105287, HL097296)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- arterial stiffness, systolic hypertension, diet-induced obesity, aortic stiffness, metabolic syndrome, aortitis, weight loss, hemodynamic load, conduit arteries
- MeSH terms
- Animals, Aorta, Blood Pressure, Diet, Hemodynamics, Hypertension, Mice, Obese, Obesity, Risk Factors, Mice, Vascular Stiffness, Pulse Wave Analysis
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