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Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus

Open access
Heida, Karst Y., Franx, Arie, van Rijn, Bas B., Eijkemans, Marinus J.C., Boer, Jolanda M.A., Verschuren, Monique W.M., Oudijk, Martijn A., Bots, Michiel L., van der Schouw, Yvonne T.·2015·Hypertension

Abstract

A prospective cohort study was conducted to assess the impact of a history of hypertensive disorder of pregnancy (HDP) or gestational diabetes mellitus (GDM) on the risk and age of onset of hypertension, type 2 diabetes mellitus (T2D), and cardiovascular disease (CVD) later in life, independent of hypertension and T2D. Between 1993 and 1997, 22 265 ever-pregnant women were included from the European Prospective Investigation into Cancer and Nutrition-NL study, aged 20 to 70 years at baseline. Details on complications of pregnancy and known hypertension were obtained by questionnaire. Blood pressure was measured at enrollment. Participants were followed for the occurrence of CVD events. Data were analyzed using ANCOVA, multivariable logistic regression, and Cox proportional hazard (with HDP and GDM as time-dependent variables for T2D and CVD) models. At enrollment, women with a HDP reported diagnosis of hypertension 7.7 years earlier (95% confidence interval [CI] 6.9–8.5) and women with GDM reported diagnosis of T2D 7.7 years earlier (95% CI 5.8–9.6) than women without pregnancy complications. After adjustment for potential confounders, HDP was associated with presence of hypertension at enrollment (odds ratio 2.12, 95% CI 1.98–2.28) and onset of CVD later in life (hazard ratio 1.21, 95% CI 1.10–1.32). After including the intermediates hypertension and T2D in the model, the risk of CVD later in life decreased (hazard ratio 1.09, 95% CI 1.00–1.20). GDM was associated with an increased risk of developing T2D later in life (hazard ratio 3.68, 95% CI 2.77–4.90), but not with risk of CVD. HDP and GDM have a substantial impact on the risk of CVD and are potentially important indicators for preventive cardiovascular risk management.

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Metadata

Authors
Heida, K. Y., Franx, A., van Rijn, B. B., Eijkemans, M. J. C., Boer, J. M. A., Verschuren, M. W. M., Oudijk, M. A., Bots, M. L., & van der Schouw, Y. T.
Venue
Hypertension
Published
2015-12
Volume
66
Issue
6
Pages
1116-1122
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
OpenAlex
W2205996758
Cited by
158
References
9
FWCI
15.88
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus. https://app.cochat.ai/papers/10.1161/hypertensionaha.115.06005
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Heida, K. Y., Franx, A., van Rijn, B. B., Eijkemans, M. J. C., Boer, J. M. A., Verschuren, M. W. M., Oudijk, M. A., Bots, M. L., & van der Schouw, Y. T. (2015). Earlier Age of Onset of Chronic Hypertension and Type 2 Diabetes Mellitus After a Hypertensive Disorder of Pregnancy or Gestational Diabetes Mellitus. Hypertension. https://doi.org/10.1161/hypertensionaha.115.06005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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