Associations of Short-Term and Long-Term Exposure to Ambient Air Pollutants With Hypertension: A Systematic Review and Meta-Analysis

Abstract

Hypertension is a major disease of burden worldwide. Previous studies have indicated that air pollution might be a risk factor for hypertension, but the results were controversial. To fill this gap, we performed a meta-analysis of epidemiological studies to investigate the associations of short-term and long-term exposure to ambient air pollutants with hypertension. We searched all of the studies published before September 1, 2015, on the associations of ozone (O 3 ), carbon monoxide (CO), nitrogen oxide (NO 2 and NO X ), sulfur dioxide (SO 2 ), and particulate matter (PM 10 and PM 2.5 ) with hypertension in the English electronic databases. A pooled odds ratio (OR) for hypertension in association with each 10 μg/m 3 increase in air pollutant was calculated by a random-effects model (for studies with significant heterogeneity) or a fixed-effect model (for studies without significant heterogeneity). A total of 17 studies examining the effects of short-term (n=6) and long-term exposure (n=11) to air pollutants were identified. Short-term exposure to SO 2 (OR=1.046, 95% confidence interval [CI]: 1.012–1.081), PM 2.5 (OR=1.069, 95% CI: 1.003–1.141), and PM 10 (OR=1.024, 95% CI: 1.016–1.032) were significantly associated with hypertension. Long-term exposure (a 10 μg/m 3 increase) to NO 2 (OR=1.034, 95% CI: 1.005–1.063) and PM 10 (OR=1.054, 95% CI: 1.036–1.072) had significant associations with hypertension. Exposure to other ambient air pollutants (short-term exposure to NO 2 , O 3 , and CO and long-term exposure to NO x , PM 2.5 , and SO 2 ) also had positive relationships with hypertension, but lacked statistical significance. Our results suggest that short-term or long-term exposure to some air pollutants may increase the risk of hypertension.