Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop
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More recent evidence in both infants and adults suggests that exceptionally high concentrations of nitrite (well beyond the <75mg nitrite necessary to achieve blood pressure effects) would be necessary to pose a significant threat to safety.
“although more recent evidence in both infants and adults suggests that exceptionally high concentrations of nitrite (and well beyond the <75mg nitrite necessary to achieve blood pressure effects) would be necessary to pose a significant threat to safety[25,51,72,113,155–158].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [155]
Nitrites in combination with dietary amines or amides, such as in red and cured meats, have been linked to stomach and several other cancers.
“Indeed, nitrites in combination with dietary amines or amides, such as in red and cured meats, have been linked to stomach and several other cancers[155,157,160,163–166].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [155]
The mutagenic potential of dietary nitrate and nitrite is likely contextual, depending on complex interactions between nitrate and nitrite with factors such as the relative content of amines, amides and plant-based antioxidant substrate.
“suggesting that the mutagenic potential of dietary nitrate and nitrite is likely contextual, depending on the complex interactions between nitrate and nitrite with factors such as the relative content of amines, amides and plant-based, antioxidant substrate[155,169].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [155]
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References 126 · Cited by 92
- Authors
- Ahluwalia, A., Gladwin, M., Coleman, G. D., Hord, N., Howard, G., Kim‐Shapiro, D. B., Lajous, M., Larsen, F. J., Lefer, D. J., McClure, L. A., Nolan, B. T., Pluta, R., Schechter, A., Wang, C., Ward, M. H., & Harman, J. L.
- Affiliations
- Queen Mary University of London (GB)
- University of Pittsburgh (US)
- University of Maryland, College Park (US)
- Oregon State University (US)
- University of Alabama at Birmingham (US)
- Wake Forest University (US)
- Nacional de Salud Pública de Mexico, Mexico, Albania
- Karolinska Institutet (SE)
- Louisiana State University Health Sciences Center New Orleans (US)
- Drexel University (US)
- United States Geological Survey (US)
- National Institute of Neurological Disorders and Stroke (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- National Center for Health Statistics (US)
- National Cancer Institute (US)
- National Heart, Lung, and Blood Institute (US)
- Corresponding author
- Ahluwalia, Amrita
- Gladwin, Mark
- Harman, Jane L.
- ORCID
- Venue
- Journal of the American Heart Association
- Published
- 2016-07-06
- Volume
- 5
- Issue
- 7
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC5015377
- OpenAlex
- W2461497625
- Cited by
- 92
- References
- 126
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 9 · 2016: 2
- FWCI
- 9.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
- Funders
- National Heart, Lung, and Blood Institute (R37HL058091)
- National Institute of General Medical Sciences (P30GM106392)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- dietary nitrate, cardiovascular disease, nitrate consumption, cardiovascular disease epidemiology, cardiovascular risk
- MeSH terms
- Cardiovascular Diseases, Diet, Heart, Humans, Nitrates, Nitric Oxide, Nitrites, United States, National Heart, Lung, and Blood Institute (U.S.)
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