Circulating osteonectin and adipokine profiles in relation to metabolically healthy obesity in Chinese children: Findings from BCAMS
Open accessAbstract
Background The role of adipokine dysregulation in determining the metabolic fate of obesity is not well studied. We aimed to examine whether the matricellular protein osteonectin and the profiles of certain adipokines could differentiate metabolically healthy obese ( MHO ) versus metabolically unhealthy obese phenotypes in childhood. Methods and Results This study included 1137 obese children and 982 normal-weight healthy ( NWH ) controls recruited from the BCAMS (Beijing Child and Adolescent Metabolic Syndrome) study. MHO was defined by the absence of insulin resistance and/or any metabolic syndrome components. Six adipokines-osteonectin, leptin, adiponectin, resistin, FGF21 (fibroblast growth factor 21), and RBP-4 (retinol binding protein 4)-were assessed. Approximately 20% of obese children displayed the MHO phenotype. MHO children had a more favorable adipokine profile than metabolically unhealthy obese children, with lower osteonectin, leptin, and RBP -4 and higher adiponectin (all P<0.05). Compared with normal-weight healthy controls, MHO children displayed increased leptin, resistin, and RBP -4 levels and reduced adiponectin concentrations (all P<0.05) but similar osteonectin and FGF 21 levels. Among obese subjects, decreased osteonectin (odds ratio [OR]: 0.82; 95% confidence interval [CI] per standard deviation, 0.70-0.97), RBP -4 (OR: 0.77; 95% CI per standard deviation, 0.64-0.93), and leptin/adiponectin ratio (OR: 0.58; 95% CI per standard deviation, 0.43-0.77) were independent predictors of MHO . In addition, compared with children without abnormalities, those with any 3 adipokine abnormalities were 80% less likely to exhibit the MHO phenotype ( OR : 0.20; 95% CI , 0.10-0.43) and 3 times more likely to have metabolic syndrome ( OR : 2.77; 95% CI , 1.52-5.03). Conclusions These findings suggest that dysregulation of adipokines might govern the metabolic consequences of obesity in children. Low osteonectin levels, along with a healthy adipokine profile, might be used as an early marker of the MHO phenotype.
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Inhibition of adipogenesis can restrict storage of triglycerides in adipose tissue, increasing circulating levels (systemic hyperlipidemia) and lipid deposition in liver and skeletal muscle.
“Therefore, the inhibition of adipogenesis can restrict the storage of triglycerides in tissue adipose, increasing circulating levels (systemic hyperlipidemia) and lipid deposition in the liver and skeletal muscle [55].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [55]
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References 58 · Cited by 37
Research works printed but not linked: 1
- [3]Samocha‐Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietilainen KH, Rabasa‐Lhoret R, Roden M, Scherer PE, Klein S, Ravussin E. Metabolically healthy and unhealthy obese—the 2013 Stock Conference report. Obes Rev. 2014; 15: 697– 708. 25059108 PMC4519075
- Authors
- Fu, J., Li, Y., Esangbedo, I. C., Li, G., Feng, D., Li, L., Xu, L., Han, L., Li, M., Li, C., Gao, S., Li, M., & Willi, S. M.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Children's Hospital of Philadelphia (US)
- Capital Medical University (CN)
- Corresponding author
- Li, Ming
- Venue
- Journal of the American Heart Association
- Published
- 2018-12-04
- Volume
- 7
- Issue
- 23
- Pages
- e009169-e009169
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC6405551
- OpenAlex
- W2901168594
- Cited by
- 37
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 8 · 2019: 3
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- metabolically healthy obesity, childhood obesity, SPARC, adipokines, leptin, adiponectin, resistin, FGF21, retinol-binding protein 4, metabolic syndrome, insulin resistance, matricellular proteins, Chinese children, leptin/adiponectin ratio, obesity phenotypes, adipose tissue inflammation, adipose tissue fibrosis
- MeSH terms
- Obesity, Metabolically Benign, Adolescent, Child, Female, Fibroblast Growth Factors, Humans, Male, Osteonectin, Case-Control Studies, Leptin, Adiponectin, Resistin, Adipokines, Retinol-Binding Proteins, Plasma, Pediatric Obesity
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