Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Macleod, Malcolm R., van der Worp, H. Bart, Sena, Emily S., Howells, David W., Dirnagl, Ulrich, Donnan, Geoffrey A.·2008·Stroke
DOI 10.1161/strokeaha.108.515957

Cited by (319)

Items 201–300 of 319

  1. Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies
    Manoj Mathew Lalu, Justin Presseau, Madison Foster, Victoria T. Hunniford, Kelly Denise Cobey, Jamie Brehaut, Carolina S. Ilkow, Joshua Ryan Montroy, Analyssa Cardenas, Ayni Sharif et al. · 2023 · PLoS Biology
  2. The effectiveness of acellular nerve allografts compared to autografts in animal models: A systematic review and meta-analysis
    Berend O. Broeren, Caroline Anna Hundepool, Ali H. Kumas, Liron S. Duraku, Erik Taco Walbeehm, Carlijn R. Hooijmans, Dominic Power, Jelle Michiel Zuidam, Tim de Jong · 2024 · PLoS ONE
  3. α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke
    José Marco‐Contelles · 2024 · Antioxidants
  4. CRIME-Q—a unifying tool for critical appraisal of methodological (technical) quality, quality of reporting and risk of bias in animal research
    Mikkel Schou Andersen, Mikkel Seremet Kofoed, Asger Sand Paludan‐Müller, Christian Bonde Pedersen, Tiit Illimar Mathiesen, Christian Mawrin, Birgitte Brinkmann Olsen, Bo Halle, Frantz Rom Poulsen · 2024 · BMC Medical Research Methodology
  5. Statistical Rigor and the Perils of Chance
    Katherine Susan Button · 2016 · eNeuro
  6. The potential of metabolic profiling for vaccine development
    January Mikolaj Weiner, Robert P. Mohney, Stefan H. E. Kaufmann · 2018 · Seminars in Immunology
  7. Investigator brochures for phase I/II trials lack information on the robustness of preclinical safety studies
    Sören Sievers, Susanne Wieschowski, Daniel Strech · 2020 · British Journal of Clinical Pharmacology
  8. Scope of Preclinical Testing Versus Quality Control Within Experiments
    Victoria E. O’Collins, Geoffrey Alan Donnan, Malcolm Robert Macleod, David William Howells · 2009 · Stroke
  9. Addressing Reproducibility: Peer Review, Impact Factors, Checklists, Guidelines, and Reproducibility Initiatives
    Michael J. Williams, Kevin Mullane, Michael J. Curtis · 2017 · Elsevier eBooks
  10. Building Robustness into Translational Research
    Betül Rabia Erdoğan, Martin Christian Michel · 2019 · Handbook of experimental pharmacology
  11. Randomization, blinding, data handling and sample size estimation in papers published in Veterinary Anaesthesia and Analgesia in 2009 and 2019
    Brittany A Munro, Paige Bergen, Daniel Pang · 2021 · Veterinary Anaesthesia and Analgesia
  12. Subarachnoid Hemorrhage
    Robert Loch Macdonald · 2017 · Elsevier eBooks
  13. Design of Meta-Analysis Studies
    Malcolm Robert Macleod, Ezgi Tanriver-Ayder, Kaitlyn Hair, Emily S. Sena · 2019 · Handbook of experimental pharmacology
  14. Mapping the preclinical to clinical evidence and development trajectory of the oncolytic virus talimogene laherparepvec (T-VEC): a systematic review
    Manoj Mathew Lalu, Garvin J. Leung, Yuan Dong, Joshua Ryan Montroy, Claire Butler, Rebecca C. Auer, Dean A. Fergusson · 2019 · BMJ Open
  15. Magnetic resonance imaging in multiple sclerosis animal models: A systematic review, meta-analysis, and white paper
    Benjamin Victor Ineichen, Pascal Sati, Tobias Granberg, Martina Absinta, Nathanael J. Lee, Jennifer Lefeuvre, Daniel S. Reich · 2020 · NeuroImage Clinical
  16. Nitrones are able to release nitric oxide in aqueous environment under hydroxyl free radical attack
    Mircea Dumitru Croitoru, Ibolya Zita FÜLÖP, Maria Cristiana Pop, Tímea Dergez, Brânduşa Mitroi, Maria Titica Dogaru, Béla Tőkés · 2011 · Nitric Oxide
  17. Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse
    Ulrich Dirnagl, Members of the MCAO-SOP Group · 2010 · Nature Precedings
  18. Neuroprotection After Traumatic Brain Injury
    Ralf Watzlawick, David William Howells, Jan Markus Schwab · 2015 · JAMA Neurology
  19. Stop Fooling Yourself! (Diagnosing and Treating Confirmation Bias)
    Richard T. Born · 2024 · eNeuro
  20. Antidepressant effect or bias? Systematic review and meta-analysis of studies using the forced swimming test
    Tamires Martins, Ana Belén Ramos-Hryb, Marcus Antonio Bezerra Da Silva, Camila Sant’ Helena do Prado, Fabiola Boz Eckert, Fabiani Fernanda Triches, Johnny E. da Costa, Juliana Aparecida Bolzan, Sarah McCann, Cilene Lino de Oliveira · 2025 · Behavioural Pharmacology
  21. Neuroprotective efficacy of N-t-butylhydroxylamine (NtBHA) in transient focal ischemia in rats
    Eun Sun Kim, Yusun Shin, Eun-Hye Kim, Donghyun Kim, Milena De Felice, Arshad Majid, Ok‐Nam Bae · 2022 · Toxicological Research
  22. Late, never or non‐existent: the inaccessibility of preclinical evidence for new drugs
    Carole A. Federico, Benjamin Gregory Carlisle, Jonathan Kimmelman, Dean A. Fergusson · 2014 · British Journal of Pharmacology
  23. Reporting in rodent models of ‘chemobrain’: a systematic review assessing compliance with the ARRIVE guidelines
    Rebecca P. George, Ines Semendric, Eleanor R. Bowley-Schubert, Christine T. Chivonivoni, Alexandra P. Warrender, Alexandra Louise Whittaker · 2021 · Supportive Care in Cancer
  24. Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research
    Timo Sander, Joly Ghanawi, Emma Wilson, Sajjad Muhammad, Malcolm Robert Macleod, Ulf D. Kahlert · 2022 · BMJ Open Science
  25. Research Wranglers: Initiatives to Improve Reproducibility of Study Findings
    Charles W. Schmidt · 2014 · Environmental Health Perspectives
  26. Allopregnanolone and Its Precursor Progesterone Do Not Reduce Injury after Experimental Stroke in Hypertensive Rats – Role of Postoperative Temperature Regulation?
    Neil James Spratt, Amelia J. Tomkins, Debbie Pepperall, Damian D. McLeod, Mike B. Calford · 2014 · PLoS ONE
  27. An empirical assessment of research practices across 163 clinical trials of tumor-bearing companion dogs
    Yuan Jin Tan, Ryan J. Crowley, John P. A. Ioannidis · 2019 · Scientific Reports
  28. Dealing with publication bias in translational stroke research
    Shimin Liu · 2009 · Journal of Experimental Stroke and Translational Medicine
  29. How to Pick a Neuroprotective Drug in Stroke Without Losing Your Mind?
    Joseph S. Tauskela, Nicolas Blondeau · 2025 · Life
  30. Treatment Strategies
    Steven C. Cramer, Randolph J. Nudo · 2010 · Cambridge University Press eBooks
  31. Synthesis and antibacterial properties of new phenothiazinyl- and phenyl-nitrones
    Hermina Iulia Petkes, Emese Gál, Luiza Găină, Mihaela Sabou, Cornelia Majdik, Luminiţa Silaghi‐Dumitrescu · 2014 · Comptes Rendus Chimie
  32. Data presentation in rodent stroke studies and the predictive value of confidence intervals.
    M. Sughrue, B. Grobelny, A. Ducruet, R. Komotar, J. Mocco, R. Sciacca, E. S. Connolly · 2010 · Journal of clinical neuroscience
  33. Two decades testing interventions in transgenic mouse models of Alzheimer's disease: designing and interpreting studies for clinical trial success
    Kieren J. Egan, Malcolm Robert Macleod · 2014 · Clinical Investigation
  34. Small molecule inhibitors in the treatment of cerebral ischemia
    Jerry J. Flores, Yang Zhang, Damon W. Klebe, Tim Lekic, Weiling Fu, John H. Zhang · 2014 · Expert Opinion on Pharmacotherapy
  35. Acupuncture does not protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in a preclinical mouse model of Parkinson’s disease
    Hui-Jun Yang, Yu Gao, Ji Young Yun, Young Eun Kim, Gwanhee Ehm, Ji Yeon Lee, Min-Yung Yoon, Young-Shin Lee, Han‐Joon Kim, Beomseok Jeon · 2016 · Neuroreport
  36. Methodological standards, quality of reporting and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review
    Joana Guilherme-Fernandes, Nuno Henrique Franco, Andrew J. Grierson, Jan Hultgren, Andrew J. Furley, I. Anna S. Olsson · 2019 · BMJ Open Science
  37. Preclinical efficacy in investigator's brochures: Stakeholders' views on measures to improve completeness and robustness
    Martin Haslberger, Susanne Gabriele Schorr, Daniel Strech, Tamarinde Laura Haven · 2022 · British Journal of Clinical Pharmacology
  38. Reproducibility in Biomedical Research
    Kevin Mullane, Michael J. Curtis, Michael J. Williams · 2017 · Elsevier eBooks
  39. Balancing sensitivity and specificity in preclinical research
    Meggie Danziger, Anja Collazo, Ulrich Dirnagl, Ulf Toelch · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  40. A case study of the informative value of risk of bias and reporting quality assessments for systematic reviews
    Cathalijn H. C. Leenaars, Frans R. Stafleu, Christine Häger, André Bleich · 2024 · Systematic Reviews
  41. Neuroinflammation in ischemic brain injury as an adaptive process
    Jack Rivers‐Auty, John C. Ashton · 2013 · Medical Hypotheses
  42. Quality of reporting of prospective in vivo and ex vivo studies published in the Journal of Veterinary Emergency and Critical Care over a 10‐year period (2009–2019)
    Paige Bergen, Brittany A Munro, Daniel Pang · 2023 · Journal of Veterinary Emergency and Critical Care
  43. Chinese Herbal Medicines for Neuroprotection in Ischemic Stroke: Promise and Reality
    Nikolaus J. Sucher, Maria Carles · 2012 · Springer eBooks
  44. Neuroanesthesia: from bench to bed
    Mishiya Matsumoto, Kazuyoshi Ishida · 2012 · Journal of Anesthesia
  45. Some Salt with Your Statin, Professor?
    Malcolm Robert Macleod · 2014 · PLoS Biology
  46. Stroke: Pathophysiology and Therapy
    Jens Minnerup, Antje Schmidt, Christiane Albert-Weißenberger, Christoph Kleinschnitz · 2013 · Colloquium Series on Integrated Systems Physiology From Molecule to Function
  47. Metabolic Reflow as a Therapy for Ischemic Brain Injury
    Hiroaki Manabe, Yi Wang, Ryo Yoshimura, Yu Cai, Mark P. Fitzgerald, Ryon H. Clarke, Kevin S. Lee · 2011 · Springer eBooks
  48. The Need to Improve Experimental Design
    Derek Fry · 2013 · Alternatives to Laboratory Animals
  49. Interleukin-1 Receptor Antagonist in Animal Models of Stroke: A Fair Summing Up?
    Adrian Parry‐Jones, Hervé Boutin, Ádám Dénes, Barry W. McColl, Steve Hopkins, Stuart McRae Allan, Pippa J. Tyrrell · 2010 · Journal of Stroke and Cerebrovascular Diseases
  50. Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse
    Ulrich Dirnagl, Ulrich Dirnagl, Members of the MCAO-SOP Group · 2010 · Nature Precedings
  51. Lost in Translation - - the challenges with the use of animal models in translational research
    Attila A. Seyhan · 2019
  52. Effect of Cilostazol in Animal Models of Cerebral Ischemia and Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis
    Adnan Iqbal Qureshi, Iqra Naveed Akhtar, Xiaoyu Ma, Abdullah Lodhi, Ibrahim Ahmad Bhatti, Jonathan Beall, Joseph P. Broderick, Christy N. Cassarly, Renee’ Hebert Martin, Rishi Sharma et al. · 2022 · Neurocritical Care
  53. Measurement of mouse head and neck tumors by automated analysis of CBCT images
    Benjamin Van Court, Brooke Neupert, Diemmy Nguyen, Richard Ross, Michael W. Knitz, Sana D. Karam · 2023 · Scientific Reports
  54. Rat Models for Ischemic Stroke
    Hyun Young Kim, Seong‐Ho Koh, Seung Hyun Kim · 2011 · Korean Journal of Stroke
  55. How to Avoid Bumping into the Translational Roadblock
    Malcolm Robert Macleod · 2010 · Neuromethods
  56. Testing the limits: can enhanced external validity promote translation?
    Aileen MacLellan, Manoj Mathew Lalu · 2024 · EBioMedicine
  57. Subacute AMD3100 Treatment Is Not Efficient in Neonatal Hypoxic-Ischemic Rats
    Daiane Aparecida Spiess, Raquel Maria Pereira Campos, Luciana Conde, Nadine Didwischus, Johannes Boltze, Rosalia Méndez‐Otero, Pedro M. Pimentel‐Coelho · 2021 · Stroke
  58. Experimental Models of Vascular Occlusions for Evaluation of Thrombectomy Devices
    Ju-Yu Chueh, Anna Luisa Kühn, Ajay K. Wakhloo, Matthew J. Gounis · 2013 · Cardiovascular Engineering and Technology
  59. Oral administration of a novel lipophilic PPARδ agonist is not neuroprotective after rodent cerebral ischemia
    S. Knauss, M. Endres, F. Blaschke, C. Hindinger, A. Kunz · 2018 · Journal of Cerebral Blood Flow and Metabolism
  60. BASIC RESEARCH IN SHOCK AND SEPSIS
    Daniel George Remick, Andrea Szabó, Nicole Petra Juffermans, Marcin Filip Osuchowski · 2022 · Shock
  61. A systematic review of the Woven EndoBridge device—do findings in pre-clinical animal models compare to clinical results?
    René Aquarius, Danique Elbertsen, Joost de Vries, Hieronymus Damianus Boogaarts, Kimberley Elaine Wever · 2023 · Acta Neurochirurgica
  62. Longer Periods of Hypothermia Provide Greater Protection Against Focal Ischemia: A Systematic Review of Animal Studies Manipulating Treatment Duration
    Megan J. Eberle, Aline B. Thorkelsson, Lane J. Liddle, Mohammed Almekhlafi, Frederick Colbourne · 2023 · Therapeutic Hypothermia and Temperature Management
  63. The Methodologists: a Unique Category of Scientific Actors
    Nicole Christine Nelson · 2020 · Engaging Science Technology and Society
  64. Metabolic and behavioural effects in offspring exposed to maternal sucrose consumption: a systematic review and meta-analysis of data from rodent models
    Heidi Morahan, Cathalijn H. C. Leenaars, Robert A. Boakes, Kieron B. Rooney · 2020 · Journal of Developmental Origins of Health and Disease
  65. A meta-analysis of animal studies evaluating the effect of hydrogen sulfide on ischemic stroke: is the preclinical evidence sufficient to move forward?
    Selda Emre Aydıngöz, Arıyan Teimoori, Halit Güner Orhan, Elif Demirtaş, Nargız Zeynalova · 2024 · Naunyn-Schmiedeberg s Archives of Pharmacology
  66. Experimental Design
    Derek Fry · 2013 · Elsevier eBooks
  67. A Systematic Review of Depth-Dependent Cytoprotection with Therapeutic Hypothermia for Cerebral Ischemia
    Marin R. Parranto, Tiffany F.C. Kung, Lane J. Liddle, Tayyaba Khalid, Aline B. Thorkelsson, Ana C. Klahr, Mohammed Almekhlafi, Frederick Colbourne · 2025 · Therapeutic Hypothermia and Temperature Management
  68. Neuroprotection Following Stroke
    D. Amantea, R. Greco · 2021 · Elsevier eBooks
  69. Nitrones: not only extraordinary spin traps, but also good nitric oxide sources in vivo
    Mircea Dumitru Croitoru, Hermina Iulia Petkes, Ibolya Zita FÜLÖP, Remus Cotârlan, Oana Elena Şerban, Maria Titica Dogaru, Andrei Şerban Gâz, Béla Tőkés, Cornelia Majdik · 2015 · Acta Pharmaceutica
  70. Challenges and Pitfalls of Stroke Therapeutics Research
    Keun‐Hwa Jung · 2011 · Korean Journal of Stroke
  71. Maximizing value and minimizing waste in clinical trial research in swine: Design features to minimize bias
    Jan Merrill Sargeant, Annette M. Cormier O'Connor, Terri L. O’Sullivan, Alejandro Ramirez · 2023 · Journal of Swine Health and Production
  72. Quality Control and Standard Operating Procedures
    Ulrich Dirnagl · 2010 · Neuromethods
  73. Identifying Low-Quality Preclinical Studies
    Justin A. Zivin · 2008 · Stroke
  74. Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents
    Ayni Sharif, Matthew Strider Jeffers, Dean A. Fergusson, Raj Bapuji, Stuart Gordon Nicholls, John Humphrey, Warren Johnston, Ed Mitchell, Mary-Ann Speirs, Laura Stronghill et al. · 2025 · eLife
  75. Activin A Reduces Brain Injury After Stroke
    Shibani S. Mukerji · 2009 · OhioLink ETD Center (Ohio Library and Information Network)
  76. Neurotoxicity and Stroke
    Victoria E. O’Collins, David William Howells, Romesh Markus · 2014 · Springer eBooks
  77. Co-transplantation Strategies and Combination Therapies for Stroke
    Aurel Popa‐Wagner, Raluca Elena Sandu, Ovidiu Ciobanu · 2016 · Springer eBooks
  78. Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke
    S. McCann, E. Sena, G. Currie, M. Macleod, D. Howells · 2017 · Springer series in translational stroke research
  79. Differential susceptibility of human neural progenitors and neurons to ischaemic injury
    Ye Liu, Anna Michalska, Mirella Dottori, Emma D. Eaton, Jo‐Maree Courtney, Ana Antonic‐Baker, David William Howells · 2019 · Brain Research Bulletin
  80. Irreproducibility –The deadly sin of preclinical research in drug development
    Sadasivan Pillai, Katsumi Kobayashi, Mathews Michael, Anita Meena · 2020 · Journal of Pre-Clinical and Clinical Research
  81. How to Avoid Bumping into the Translational Roadblock
    Malcolm Robert Macleod, Emily S. Sena · 2016 · Neuromethods
  82. A companion to the preclinical common data elements for rigor, reproducibility and transparency in basic and translational epilepsy research. A report of the TASK3 ‐ WG1A : Pharmacology Working Group of the ILAE / AES Joint Translational Task Force
    Brian D. Klein, Lauren C. Harte‐Hargrove, Wenzhu Bi Mowrey, Aristea S. Galanopoulou, Cameron S. Metcalf, Lisa D. Coles, Patrick Alexander Forcelli, Anna‐Maria Katsarou, Rüdiger Köhling, Karine Leclercq et al. · 2025 · Epilepsia Open
  83. Do We Need a Science of Science?
    Ülo Maiväli · 2015 · Elsevier eBooks
  84. Marrow-Derived Mesenchymal Stromal Cells in the Treatment of Stroke
    Steven C. Cramer · 2016 · Springer eBooks
  85. Systematic Reviews
    Janet Becker Rodgers, Merel J. Ritskes-Hoitinga · 2021 · Laboratory animal science and medicine
  86. Meta‐analysis of the effects of anti‐migraine therapeutics in the rat trigeminovascular nociception model as a tool for design optimization
    A. Dolgorukova, E. Protsenko, J. Isaeva, Victoria Gagloeva, E. Verbitskaya, R. Berkovich, A. Sokolov · 2023 · European Journal of Neuroscience
  87. Studies on poly-ICLC treatment as a potent neuroprotective therapy against ischemic brain injury
    Amy E.B. Packard · 2015
  88. Animal Models of Stroke
    Lisa C. Hoyte, Alastair Mitchell Buchan · 2009 · Elsevier eBooks
  89. Increasing value and reducing waste in animal models of rheumatological disease
    Gillian L. Currie, Malcolm Robert Macleod · 2015 · International Journal of Rheumatic Diseases
  90. Comments, Opinions, and Reviews Good Laboratory Practice Preventing Introduction of Bias at the Bench
    Malcolm Robert Macleod, Marc Fisher, Victoria E. O’Collins, Emily S. Sena, Ulrich Dirnagl, Alastair Mitchell Buchan, H. Bart van der Worp, Richard J. Traystman, Kazuo Minematsu, Geoffrey Alan Donnan et al. · 2009
  91. Hyperglycemia in Experimental Cerebral Ischemia
    M Molnár · 2015 · Uppsala University Publications (Uppsala University)
  92. Open Access EDITORIAL
    Jens Minnerup, Heike Wersching, Wolf‐Rüdiger Schäbitz · 2010
  93. Authors’ Response to: Letters re MVA85A
    Emily S. Sena, Taryn Young, Rufaro Kashangura, Paul Garner · 2016 · International Journal of Epidemiology
  94. Monomeric, dimeric and tetrameric triazoles which also include nitrones
    Mohamed Abdallah Ameen · 2017 · Journal of Chemical Research
  95. Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury
    Peter Batchelor, Taryn E. Wills, Peta Skeers, Camila R. Battistuzzo, Malcolm Robert Macleod, David William Howells, Emily S. Sena · 2016
  96. 뇌졸중 치료 연구의 한계점과 도전: 기초 및 중개 뇌졸중 연구 최신지견
    정근화 · 2011
  97. Practical statistical considerations for investigating anti-tumor treatments in mice
    David Lee Gold, Lixin Lang, Kim E. Zerba · 2018 · Journal of Applied Statistics
  98. Faculty Opinions recommendation of Animal models of chemotherapy-induced peripheral neuropathy: A machine-assisted systematic review and meta-analysis.
    Paul W. Farquhar-Smith, Richard Gordon-Williams · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  99. Stroke and translational research
    Chandril Chugh · 2022 · Elsevier eBooks
  100. Quality Control and Standard Operating Procedures
    Ulrich Dirnagl · 2016 · Neuromethods