Sudden Sensorineural Hearing Loss Increases the Risk of Stroke: A 5-Year Follow-Up Study
Abstract
Background and Purpose— No previous study has investigated the incidence or risk of cerebrovascular diseases developing after the sudden sensorineural hearing loss (SSNHL). This study sets out to estimate the risk of stroke development among SSNHL patients during a 5e-year follow-up period after hospitalization for acute episodes of SSNHL. Methods— Our study design features a study cohort and a comparison cohort. The study cohort consists of all patients hospitalized with a principal diagnosis of sudden hearing loss (n=1,423), whereas the control cohort comprised all patients hospitalized for an appendectomy in 1998 (n=5692) as a surrogate for the general population. Each patient was tracked from hospitalization in 1998 until the end of 2003. Cox proportional hazard regressions were performed as a means of computing the 5-year stroke-free survival rates after adjustment for possible confounding factors. Results— Of the total sample, 621 patients (8.7%) had strokes during the 5-year follow-up period: 180 (12.7% of the SSNHL patients) from the study cohort and 441 (7.8% of patients undergoing an appendectomy) from the control cohort. After adjusting for other factors, the hazard of stroke during the 5-year follow-up period was 1.64-times (95% CI, 1.31 to 2.07; P <0.001) greater for SSNHL patients than for appendectomy patients. Conclusions— Our findings suggest that SSNHL can be an early warning sign of impending stroke. We suggest that SSNHL patients should undergo a comprehensive hematologic and neurological examination to help clinicians identify those potentially at risk for stroke developing in the near future.
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Several studies have reported an association between ISSNHL and DM.
“Several studies have reported an association between ISSNHL and DM [25-29]”
From Prognostic Factors Associated with Recovery from Recurrent Idiopathic Sudden Sensorineural Hearing Loss: Retrospective Analysis and Systematic Review (2022) · cites this paper as [29]
The Results and Table 1 report an association: diabetes was recorded in 10.1% of SSNHL patients versus 4.3% of appendectomy patients (P<0.001). However, the Study Sample and Discussion identify patients by a sudden-hearing-loss diagnosis code, without establishing that their hearing loss was idiopathic. The source therefore supports an association for SSNHL, but not specifically for ISSNHL. (LLM, conf=0.82)
Experimental — accuracy not yet measuredISSNHL has been reported to be associated with a history of hypertension, chronic kidney disease, diabetes mellitus, hypercholesterolemia, and stroke.
“ISSNHL has been reported to be associated with a history of hypertension (HTN), chronic kidney disease, diabetes mellitus (DM), hypercholesterolemia, and stroke [25-29].”
From Prognostic Factors Associated with Recovery from Recurrent Idiopathic Sudden Sensorineural Hearing Loss: Retrospective Analysis and Systematic Review (2022) · cites this paper as [29]
The Results (Table 1) show that SSNHL patients had higher rates of hypertension, diabetes, and hyperlipidemia than controls. Renal disease did not differ significantly (P=0.784), and the study links SSNHL to subsequent stroke, not a history of stroke. The paper uses hyperlipidemia rather than the narrower term hypercholesterolemia. (LLM, conf=0.88)
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Research works printed but not linked: 21
- Wu CS, Lin HC, Chao PZ. Sudden sensorineural hearing loss: evidence from Taiwan. Audiol Neurootol. 2006;11:151-156.
- Lin HC, Lee HC, Chao PZ, Wu CS. The effects of weather on the incidence of sudden sensorineural hearing loss: a 5-year population-based study. Audiol Neurootol. 2006;11:165-171.
- Merchant SN, Adams JC, Nadol JB Jr. Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss. Otol Neurotol. 2005;26: 151-160.
- Vasama JP, Linthicum FH Jr. Idiopathic sudden sensorineural hearing loss: temporal bone histopathologic study. Ann Otol Rhinol Laryngol. 2000;109:527-532.
- Lazarini PR, Camargo AC. Idiopathic sudden sensorineural hearing loss: etiopathogenic aspects. Rev Bras Otorrinolaringol (Engl Ed). 2006;72: 554 -561.
- Patzak MJ, Demuth K, Kehl R, Lindner A. Sudden hearing loss as the leading symptom of an infarction of the left anterior inferior cerebellar artery. HNO. 2005;53:797-799.
- Deschauer M, Georgiadis D, Lindner A. Hearing loss as the leading symptom in anterior inferior cerebellar artery infarction. Fortschr Neurol Psychiatr. 1998;66:109 -112.
- Oshiro S, Ohmura T, Fukushima T. Unilateral sudden deafness as a primary symptom of brainstem and cerebellar infarction. No To Shinkei. 2006;58:807-812.
- Yi HA, Lee SR, Lee H, Ahn BH, Park BR, Whitman GT. Sudden deafness as a sign of stroke with normal diffusion-weighted brain MRI. Acta Otolaryngol. 2005;125:1119 -1121.
- Lee H, Whitman GT, Lim JG, Lee SD, Park YC. Bilateral sudden deafness as a prodrome of anterior inferior cerebellar artery infarction. Arch Neurol. 2001;58:1287-1289.
- Lee H, Sohn SI, Jung DK, Cho YW, Lim JG, Yi SD, Lee SR, Sohn CH, Baloh RW. Sudden deafness and anterior inferior cerebellar artery infarction. Stroke. 2002;33:2807-2812.
- Lee H, Cho YW. Auditory disturbance as a prodrome of anterior inferior cerebellar artery infarction. J Neurol Neurosurg Psychiatry. 2003;74: 1644 -1648.
- Lin HC, Tsai SY, Lee HC. Increased risk of developing stroke among patients with bipolar disorder after an acute mood episode: a six-year follow-up study. J Affect Disord. 2007;100:49 -54.
- Lin HC, Tsai SY, Lee HC. No higher risk of myocardial infarction among bipolar patients in a 6-year follow-up of acute mood episodes. Psychosom Med. 2008;70:73-76.
- Lin HC, Lin YJ, Liu TC, Chen CS, Chiu WT. Urbanization and stroke prevalence in Taiwan: analysis of a nationwide survey. J Urban Health. 2007;84:604 -614.
- Engstrom G, Jerntorp I, Pessah-Rasmussen H, Hedblad B, Berglund G, Janzon L. Geographic distribution of stroke incidence within an urban population: relations to socioeconomic circumstances and prevalence of cardiovascular risk factors. Stroke. 2001;32:1098 -1103.
- Liu CY, Hung YT, Chuang YL, Chen YJ, Weng WS, Liu JS Liang KY. Incorporating development stratification of Taiwan townships into sampling design of large scale health interview survey (in Chinese). J Health Manage. 2006;4:1-22.
- Suckfu ¨ll M, Wimmer C, Reichel O, Mees K, Schorn K. Hyperfibrino- genemia as a risk factor for sudden hearing loss. Otol Neurotol. 2002; 23:309 -311.
- Rudack C, Langer C, Stoll W, Rust S, Walter M. Vascular risk factors in sudden hearing loss. Thromb Haemost. 2006;95:454 -461.
- Suckfu ¨ll M, Thiery J, Wimmer C, Mees K, Schorn K. Hypercholes- teremia and hyperfibrinogenemia in sudden deafness. Laryngorhinoot- ologie. 1997;76:453-457.
- Nomura K, Nakao M, Morimoto T. Effect of smoking on hearing loss: quality assessment and meta-analysis. Prev Med. 2005;40:138 -144.
Cited by
Sorted by citations
Mick, P., Reed, M., & Pichora-Fuller, M. (2015) · Seminars in Hearing · doi:10.1055/s-0035-1555116 · Cited by 138 · see citing works
Jeon, S. Y., Kang, D. W., Kim, S. H., Byun, J. Y., & Yeo, S. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051453 · Cited by 9 · see citing works
- Authors
- Lin, H.-C., Chao, P.-Z., & Lee, H.-C.
- Affiliations
- Taipei Medical University (TW)
- Venue
- Stroke
- Published
- 2008-10
- Volume
- 39
- Issue
- 10
- Pages
- 2744-2748
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2014423053
- Cited by
- 220
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 10 · 2023: 14 · 2022: 12 · 2021: 12 · 2020: 14 · 2019: 8 · 2018: 11 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 14 · 2013: 15 · 2012: 31
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
- Keywords
- sudden sensorineural hearing loss, stroke risk, cerebrovascular disease, stroke incidence, stroke-free survival
- MeSH terms
- Adult, Aged, Hearing Loss, Sudden, Female, Follow-Up Studies, Humans, Male, Middle Aged, Risk, Risk Factors, Case-Control Studies, Stroke, Kaplan-Meier Estimate
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