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Cited by 80Cardiac electrophysiology and arrhythmiasAcute Ischemic Stroke ManagementCardiac Arrhythmias and Treatments

Premature Ventricular Complexes and the Risk of Incident Stroke: The Atherosclerosis Risk In Communities (ARIC) Study

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Agarwal, Sunil K., Heiss, Gerardo, Rautaharju, Pentti M., Shahar, Eyal, Massing, Mark W., Simpson, Ross J.·2010·Stroke
DOI 10.1161/strokeaha.109.567800PMC PMC2866170
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Abstract

Background and Purpose— Premature ventricular complexes (PVCs) on a 2-minute electrocardiogram are a common, largely asymptomatic finding associated with increased risk of coronary heart disease and death. They may reflect atherosclerosis or other pathogenic pathways that predispose to arrhythmias and stroke. Methods— We conducted a prospective evaluation of the Atherosclerosis Risk In Communities Study cohort (n=14 783) of middle-aged men and women to assess whether the presence of PVCs at study baseline (1987 to 1989) influenced the risk of incident stroke through December 31, 2004. Results— PVCs were seen in 6.1% of the participants at baseline, and 729 (4.9%) had incident stroke. The unadjusted cumulative proportion of incident stroke in individuals with any PVC was 6.6% compared with 4.1% in those without PVC. The unadjusted hazard ratio of incident stroke in individuals with any PVC compared with those without any PVCs was 1.71 (95% CI, 1.33 to 2.20). Among individuals without hypertension and diabetes at baseline, PVCs were independently associated with incident stroke (hazard ratio: 1.72; 95% CI: 1.14 to 2.59). Among those with either diabetes or hypertension, the presence of any PVCs did not increase the risk of stroke. The association was stronger for noncarotid embolic stroke than for thrombotic stroke and its magnitude increased with higher frequency of PVCs. Conclusions— Frequent PVCs are associated with risk of incident stroke in participants free of hypertension and diabetes. This suggests that PVCs may contribute to atrioventricular remodeling or may be a risk marker for incident stroke, particularly embolic stroke.

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  • PVCs in the structurally normal heart are considered benign, though they have been associated with a more than two-fold higher risk of cardiovascular complications, including stroke and death.

    “In general, PVCs in the structurally normal heart are considered benign [2], though they have been associated with a more than two-fold higher risk of cardiovascular complications, including stroke [3] and death [4].”

    From The effect of the physical activity on polymorphic premature ventricular complexes in chronic kidney disease (2017) · cites this paper as [3]

    Citation [3] is attached to the stroke association, not the statements about benign PVCs or death. The Results report a more than two-fold stroke hazard for participants without major stroke risk factors (HR 2.09), but not for the cohort overall (unadjusted HR 1.71; age-, gender-, and race-adjusted HR 1.4). The sentence omits the subgroup qualification needed for its magnitude claim. No page numbers are supplied for these passages. (LLM, conf=0.88)

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Cites

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Research works printed but not linked: 21

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Cited by

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Authors
Agarwal, S. K., Heiss, G., Rautaharju, P. M., Shahar, E., Massing, M. W., & Simpson, R. J.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-04
Volume
41
Issue
4
Pages
588-593
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/strokeaha.109.567800
PMC
PMC2866170
OpenAlex
W2071172543
Cited by
80
References
1
Citations by year
2026: 4 · 2025: 7 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 2 · 2015: 10 · 2014: 4 · 2013: 3 · 2012: 3
FWCI
2.41
Type
journal article
Language
en
Open access
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (n01hc55021-47-0-1, n01hc55020-39-0-0, n01hc55016-37-0-0, n01hc055022-024, n01hc55019-35-0-1, n01hc55018-38-0-1, n01hc55015-48-0-1)
  • National Heart, Lung, and Blood Institute (N01-HC55022, N01 HC055016, N01-HC-55018, N01 HC 55020, N01 HC 55019, N01 HC055020, N01 HC055018, ­N01-HC55016, N01 HC055022, N01 HC055019, N01‐HC‐55015, N01-HC55021, N01 HC055021, N01 HC055015)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Keywords
premature ventricular contractions, incident stroke, ventricular arrhythmias, embolic stroke, thrombotic stroke, hypertension, diabetes mellitus, stroke risk factors, Atherosclerosis Risk in Communities Study
MeSH terms
Electrocardiography, Female, Humans, Interviews as Topic, Male, Middle Aged, Prospective Studies, Risk Factors, Multivariate Analysis, Ventricular Premature Complexes, Stroke, Atherosclerosis

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