Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment

Candelario-Jalil, Eduardo, Thompson, Jeffrey, Taheri, Saeid, Grossetete, Mark, Adair, John C., Edmonds, Elaine, Prestopnik, Jillian, Wills, John +1 more·2011·Stroke

DOI 10.1161/strokeaha.110.600825

Cited by (172)

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Lotfy A. M, Waleed Barakat, Abd El ghany R.H · 2015 · Zagazig Journal of Pharmaceutical Sciences/Zagazig Journal of Pharmaceutical Science
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