Low levels of low-density lipoprotein-C associated with proprotein convertase subtilisin kexin 9 inhibition do not increase the risk of hemorrhagic transformation

Tran-Dinh, Alexy; Levoye, Angélique; Lambert, Gilles; Louedec, Liliane; Journé, Clément; Meilhac, Olivier; Amarenco, Pierre

doi:10.1161/strokeaha.114.005958

Low levels of low-density lipoprotein-C associated with proprotein convertase subtilisin kexin 9 inhibition do not increase the risk of hemorrhagic transformation

Background and purpose Low levels of low-density lipoprotein-cholesterol (LDL-C) are suspected to be associated with a risk of hemorrhagic transformation after ischemic stroke. We assessed the risk of hemorrhagic transformation after cerebral ischemia/reperfusion in mice with low levels of LDL-C …