Reporting standards for preclinical studies of stroke therapy
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For hypothesis-testing experiments, the sample size needs to be justified to ensure experiments are of an optimal size to test the research question.
“For hypothesis-testing experiments, in which inferential statistics are used to estimate the size of the effect and to determine the weight of evidence against the null hypothesis, the sample size needs to be justified to ensure experiments are of an optimal size to test the research question [33,34] (see Item 13. Objectives).”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [33]
To ensure scientific rigour, inclusion and exclusion criteria should be defined before the experiment starts and data are collected.
“To ensure scientific rigour, the criteria should be defined before the experiment starts and data are collected [8,33,48,49].”
From Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0 (2020) · cites this paper as [33]
Cites
A call for transparent reporting to optimize the predictive value of preclinical research
Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature · doi:10.1038/nature11556 · Cited by 1,196 · see citing works
Self-citationKilkenny, C., Parsons, N., Kadyszewski, E., Festing, M. F. W., Cuthill, I. C., Fry, D., Hutton, J., & Altman, D. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007824 · Cited by 860 · see citing works
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Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000411 · Cited by 2,677 · see citing works
Moon, G. J., Sung, J. H., Kim, D. H., Kim, E. H., Cho, Y. H., Son, J. P., Cha, J. M., & Bang, O. Y. (2019) · Translational Stroke Research · doi:10.1007/s12975-018-0668-1 · Cited by 166 · see citing works
Ramirez, F. D., Motazedian, P., Jung, R. G., Di Santo, P., MacDonald, Z. D., Moreland, R., Simard, T., Clancy, A. A., Russo, J. J., Welch, V. A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.310628 · Cited by 138 · see citing works
“These principles and guidelines have been endorsed by prominent academic societies, associations, and journals, including all American Heart Association (AHA) journals,(25) with evidence of editorial commitment to complying.(27,28) However, there are limited data on the extent of suboptimal methodological rigor or inc…”
- Authors
- Vahidy, F., Schäbitz, W.-R., Fisher, M., & Aronowski, J.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Venue
- Stroke
- Published
- 2016-10
- Volume
- 47
- Issue
- 10
- Pages
- 2435-2438
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2520169979
- Cited by
- 39
- References
- 2
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 5
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
- Keywords
- reporting guidelines, preclinical research, stroke treatment, reporting quality, clinical translation
- MeSH terms
- Animals, Disease Models, Animal, Humans, Research Design, Stroke, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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