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Cited by 66Clinical Laboratory Practices and Quality ControlCentral Venous Catheters and HemodialysisBlood transfusion and management

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Critical review and meta-analysis of spurious hemolysis in blood samples collected from intravenous catheters

Open access
Lippi, Giuseppe, Cervellin, Gianfranco, Mattiuzzi, Camilla·2013·Biochemia Medica
DOI 10.11613/bm.2013.022PMC PMC3900066
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Abstract

BACKGROUND: A number of preanalytical activities strongly influence sample quality, especially those related to sample collection. Since blood drawing through intravenous catheters is reported as a potential source of erythrocyte injury, we performed a critical review and meta-analysis about the risk of catheter-related hemolysis. MATERIALS AND METHODS: We performed a systematic search on PubMed, Web of Science and Scopus to estimate the risk of spurious hemolysis in blood samples collected from intravenous catheters. A meta-analysis with calculation of Odds ratio (OR) and Relative risk (RR) along with 95% Confidence interval (95% CI) was carried out using random effect mode. RESULTS: Fifteen articles including 17 studies were finally selected. The total number of patients was 14,796 in 13 studies assessing catheter and evacuated tubes versus straight needle and evacuated tubes, and 1251 in 4 studies assessing catheter and evacuated tubes versus catheter and manual aspiration. A significant risk of hemolysis was found in studies assessing catheter and evacuated tubes versus straight needle and evacuated tubes (random effect OR 3.4; 95% CI = 2.9-3.9 and random effect RR 1.07; 95% CI = 1.06-1.08), as well as in studies assessing catheter and evacuated tubes versus catheter and manual aspiration of blood (OR 3.7; 95% CI = 2.7-5.1 and RR 1.32; 95% CI = 1.24-1.40). CONCLUSIONS: Sample collection through intravenous catheters is associated with significant higher risk of spurious hemolysis as compared with standard blood drawn by straight needle, and this risk is further amplified when intravenous catheter are associated with primary evacuated blood tubes as compared with manual aspiration.

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  • Catheter blood collection increases the risk of hemolysis.

    “We discourage blood sampling from an intravenous catheter, as it has been shown by many studies that catheter blood collection increases the risk of hemolysis [2], [3], [4].”

    From Joint EFLM-COLABIOCLI Recommendation for venous blood sampling (2018) · cites this paper as [2]

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References 36 · Cited by 66

Research works printed but not linked: 32

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Metadata

Authors
Lippi, G., Cervellin, G., & Mattiuzzi, C.
Affiliations
Ospedale di Parma (IT)
Corresponding author
Lippi, Giuseppe
ORCID
Venue
Biochemia Medica
Publisher
Croatian Society for Medical Biochemistry and Laboratory Medicine
Published
2013
Volume
23
Issue
2
Pages
193-200
ISSN
  • 1330-0962 (ISSN-L)
  • 1846-7482
DOI
10.11613/bm.2013.022
PMC
PMC3900066
OpenAlex
W2141045421
Cited by
66
References
36
Citations by year
2026: 2 · 2025: 1 · 2024: 5 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 12 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 2
FWCI
0.62
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Biochemia Medica (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Hrčak Portal of scientific journals of Croatia (University Computing Centre) (submittedVersion, other-oa)
Topics
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Central Venous Catheters and Hemodialysis
  • Health Sciences › Medicine › Hematology › Blood transfusion and management
Keywords
intravenous catheters, blood sampling, pre-analytical variables, manual vacuum aspiration, sample quality
MeSH terms
Catheters, Indwelling, Hemolysis, Humans, Veins

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