Dissociative effects of methylphenidate in nonhuman primates: trade-offs between cognitive and behavioral performance
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Low doses of methylphenidate reduce hyperactivity and improve attention in individuals with attention deficit hyperactivity disorder (ADHD) as well as in healthy humans and animals. Despite its extensive use, relatively little is known about its mechanisms of action. This study investigated the effects of methylphenidate on working memory performance, impulsivity, response accuracy and precision, and the ability to stay on task in rhesus monkeys using an oculomotor delayed response task. Methylphenidate affected task performance in an inverted-U manner in all three subjects tested. The improvements resulted from a reduction in premature responses and, importantly, not from improvement in the memory of target location. The length of time subjects participated in each session was also affected dose dependently. However, the dose at which the length of participation was maximally increased significantly impaired performance on the working memory task. This dissociation of effects has implications for the treatment of ADHD, for the nonprescription use of methylphenidate for cognitive enhancement, and for furthering the basic understanding of the neural substrate underlying these processes.
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We can explore the specific effect of ADHD medication on said circuits.
“and explore the specific effect of ADHD medication on said circuits (e.g. [76]).”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [76]
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References 41 · Cited by 21
- Authors
- Rajala, A. Z., Henriques, J. B., & Populin, L. C.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2012-06-01
- Volume
- 24
- Issue
- 6
- Pages
- 1371-1381
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- PMC
- PMC3409297
- OpenAlex
- W1989072702
- Cited by
- 21
- References
- 41
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (DC-003693, R01DC003693)
- National Center for Research Resources (P51RR000167)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- methylphenidate, attention deficit hyperactivity disorder, working memory, impulsivity, rhesus monkeys, dose-response relationship, cognitive enhancement, task persistence, premature responses
- MeSH terms
- Administration, Oral, Animals, Cognition, Dissociative Disorders, Dose-Response Relationship, Drug, Impulsive Behavior, Macaca mulatta, Male, Memory, Short-Term, Methylphenidate, Photic Stimulation, Primates, Psychomotor Performance, Reaction Time
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