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Cited by 268

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Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure.

Iwai, K, Mori, T, Yamada, N, Yamaguchi, M, Hosoda, Y·1994·American Journal of Respiratory and Critical Care Medicine

Abstract

Idiopathic pulmonary fibrosis (IPF) risk-related factors were epidemiologically investigated on the basis of 1,311 Japanese IPF autopsy cases selected from the annual complications of autopsy data records in Japan during a 12-yr period. Age and sex distribution of the subjects revealed a high peak in their seventh decade with males predominating. The IPF rate was more than two times higher (p < 0.01) among subjects engaged in occupations that exposed them to dust or organic solvents compared with those in other jobs. To ascertain job characteristics, an autopsy-case control study was conducted using other annual volumes of the autopsy data records and a similar tendency was observed. Then, a live-case control study was undertaken of 86 subjects with IPF. A significantly higher odds ratio was noted among metal production workers and miners compared with healthy and hospital control subjects (1.37 and 1.34, respectively, p < 0.01), and also a significantly lower odds ratio among subjects who frequently eat fish. Taken together with results of recent in vitro studies, the intrapulmonary deposition of hazardous dusts, especially metallic dusts, appears to play at least a partial role in initiating IPF.

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Metadata

Authors
Iwai, K., Mori, T., Yamada, N., Yamaguchi, M., & Hosoda, Y.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
1994-09
Volume
150
Issue
3
Pages
670-675
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W2063561303
Cited by
268
References
0
FWCI
4.45
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure. https://app.cochat.ai/papers/10.1164/ajrccm.150.3.8087336
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Iwai, K., Mori, T., Yamada, N., Yamaguchi, M., & Hosoda, Y. (1994). Idiopathic pulmonary fibrosis. Epidemiologic approaches to occupational exposure. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.150.3.8087336

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.