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Cited by 346

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure.

Naughton, M T, Liu, P P, Bernard, D C, Goldstein, R S, Bradley, T D·1995·American Journal of Respiratory and Critical Care Medicine

Abstract

A previous uncontrolled study suggested that nasal continuous positive airway positive airway pressure (NCPAP) may improve left ventricular ejection fraction (LVEF) in patients with congestive heart failure (CHF) and Cheyne-Stokes respiration with central sleep apnea (CSR-CSA). In order to more critically evaluate the effects of NCPAP on cardiac function, we undertook a randomized, controlled trial of NCPAP in 29 patients with heart failure and CSR-CSA over a 3-mo period, with LVEF as the primary outcome measure. Patients with CHF and associated CSR-CSA who were receiving optimal medical therapy were randomly assigned to a control group (n = 15) or a group receiving nightly NCPAP (n = 14). Twelve patients in each group completed the study. There was a greater improvement of LVEF in the NCPAP group than in the control group during the study (mean +/- SEM = 7.7 +/- 2.5 versus - 0.5 +/- 1.5%, p = 0.019). In addition, there was a significantly greater reduction in the number of apneas and hypopneas (-28.5 +/- 3.9 versus -6.1 +/- 7.0 per hour of sleep, p = 0.012) in the NCPAP group than in the control group. Significantly greater improvements in symptoms of fatigue (5.6 +/- 1.2 versus 0.8 +/- 0.7, p = 0.005) and disease mastery (3.6 +/- 1.1 versus -0.7 +/- 0.7, p = 0.031) were also observed in the NCPAP group. We conclude that in patients with chronic heart failure and CSR-CSA, nightly administration of NCPAP can attenuate CSR-CSA, improve cardiac function, and alleviate symptoms of heart failure.

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Metadata

Authors
Naughton, M. T., Liu, P. P., Bernard, D. C., Goldstein, R. S., & Bradley, T. D.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
1995-01
Volume
151
Issue
1
Pages
92-97
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W2002496535
Cited by
346
References
5
FWCI
8.45
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure. https://app.cochat.ai/papers/10.1164/ajrccm.151.1.7812579
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Naughton, M. T., Liu, P. P., Bernard, D. C., Goldstein, R. S., & Bradley, T. D. (1995). Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.151.1.7812579

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