The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders.
Abstract
The contribution of muscle strength to symptom intensity and work capacity was examined in normal individuals and patients with cardiorespiratory disorders. Respiratory muscle strengths (maximal inspiratory and expiratory pressures) and peripheral muscle strengths (leg extension, leg flexion, seated bench press, and seated row) were measured in 4,617 subjects referred for clinical exercise testing. Subjects then rated the intensity of leg effort, discomfort with breathing (dyspnea), and chest pain (Borg scale) during an incremental exercise task (100 kpm/min each minute) to capacity on a cycle ergometer. Subjects were classified into groups on the basis of pulmonary function, drug therapy for cardiac disorders, and the presence of chest pain during exercise with electrocardiographic changes indicative of myocardial ischemia. Respiratory and peripheral muscle strengths, normalized for differences in age, sex, and height, were significantly reduced in patients with cardiorespiratory disorders compared with normal individuals. Muscle strength was a significant contributor to symptom intensity and work capacity in both health and disease; a two-fold increase in muscle strength was associated with a 25 to 30% decrease in the intensity of both leg effort and dyspnea and a 1.4- to 1.6-fold increase in work capacity. These results emphasize the need for an integrative approach in the assessment and therapeutic management of exercise intolerance, which considers the contribution of muscle weakness to excessive symptoms and reduced work capacity, in addition to the contribution of ventilatory, gas exchange, and circulatory impairments.
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Cited by
Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
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Metadata
- Authors
- Hamilton, A. L., Killian, K. J., Summers, E., & Jones, N. L.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-12
- Volume
- 152
- Issue
- 6
- Pages
- 2021-2031
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2149324635
- Cited by
- 572
- References
- 19
- FWCI
- 23.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamilton, A. L., Killian, K. J., Summers, E., & Jones, N. L. (1995). Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.152.6.8520771
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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