The DOI matches its Crossref record.
Proinflammatory Activity in Bronchoalveolar Lavage Fluids From Patients With ARDS, a Prominent Role for Interleukin-1
Abstract
Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1) have been found to be elevated in bronchoalveolar lavage (BAL) fluid and in plasma from patients with acute respiratory distress syndrome (ARDS). In order to measure the balance of proinflammatory cytokines and their inhibitors, we quantified the upregulation of intercellular adhesion molecules (ICAM-1) induced by ARDS BAL fluids in human alveolar type II-like (A459) cells, and defined proinflammatory activity as the amount of ICAM-1 induced by the SAL fluids. Proinflammatory activity was detected in 77% of the SAL fluids sampled during the first week of ARDS, was found maximal during the 3 first days after onset of ARDS, and was significantly greater than in BAL specimens from at risk patients. Blocking experiments with specific inhibitors of TNF and IL-1 added to the BAL fluids indicated that the bioactivity measured was mainly due to IL-1. In contrast, proinflammatory activity of conditioned supernates from endotoxin-treated alveolar macrophages was mostly due to TNF. Using a bioassay that measures balance of cytokines with their inhibitors, our results indicate that the net proinflammatory activity in ARDS BAL fluids is attributable to IL-1 and not to TNF.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“IL-1 is a key cytokine driving proinflammatory activity in bronchoalveolar lavage fluid of patients with lung injury (118).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [118]
Citations
Cited by
Sorted by citations
The Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
“IL-1 is a key cytokine driving proinflammatory activity in bronchoalveolar lavage fluid of patients with lung injury (118).”
BackgroundSelf-citationHeightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients
Zhou, Z. L., Ren, L., Zhang, L., Zhong, J., Xiao, Y., Jia, Z., Guo, L., Yang, J., Wang, C., Jiang, S., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.017 · Cited by 980
“Because IL-1b was recognized as the key cytokine driving proinflammatory response in BALF from patients with ARDS (Pugin et al., 1996), it is possible that the ratio of IL-1b to its inhibitor, IL-1Ra,may correlate to inflammation intensity in COVID-19 patients; however, we did not observe clear correlation in the curr…”
InfluentialNeutrophils and acute lung injury
Abraham, E. H. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000057843.47705.e8 · Cited by 849
“In patients with ALI, IL-1 is the major inflammatory mediator in bronchoalveolar lavage (15).”
Background
Metadata
- Authors
- Pugin, J., Ricou, B., Steinberg, K. P., Suter, P. M., & Martin, T. R.
- Affiliations
- University Hospital of Geneva (CH)
- Venue
- American journal of respiratory and critical care medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-06-01
- Volume
- 153
- Issue
- 6
- Pages
- 1850-1856
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2015667478
- Cited by
- 323
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 14 · 2014: 10 · 2013: 16 · 2012: 18
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (P50HL030542, HL-30542)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- acute respiratory distress syndrome, bronchoalveolar lavage fluid, interleukin-1, TNF-α, inflammatory cytokines, ICAM-1, alveolar macrophages, endotoxin, cytokine inhibitors, lung inflammation
- MeSH terms
- Adult, Aged, Bronchoalveolar Lavage Fluid, Humans, Inflammation, Interleukin-1, Lung Neoplasms, Middle Aged, Prospective Studies, Respiratory Distress Syndrome, Time Factors, Tumor Necrosis Factor-alpha, Case-Control Studies, Macrophages, Alveolar
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
