The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Diesel Exhaust Particles Enhance Antigen-induced Airway Inflammation and Local Cytokine Expression in Mice
Abstract
Previous experimental studies have suggested that nasal instillation of diesel exhaust particles (DEP) can enhance nasal IgE response and cytokine production. However, there is no experimental evidence for the relation of DEP to allergic asthma. We investigated the effects of DEP inoculated intratracheally on antigen-induced airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin production in mice. DEP aggravated ovalbumin-induced airway inflammation characterized by infiltration of eosinophils and lymphocytes and an increase in goblet cells in bronchial epithelium. DEP with antigen markedly increased interleukin-5 (IL-5) protein levels in lung tissue and bronchoalveolar lavage supernatants compared with either antigen or DEP alone. The combination of DEP and antigen induced significant increases in local expression of IL-4, granulocyte macrophage-colony stimulating factor (GM-CSF), and IL-2, whereas expression of interferon-gamma was not affected. In addition, DEP exhibited adjuvant activity for the antigen-specific production of IgG and IgE. These results provide the first experimental evidence that DEP can enhance the manifestations of allergic asthma. The enhancement may be mediated mainly by the increased local expression of IL-5, and also by the modulated expression of IL-4, GM-CSF, and IL-2.
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Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice
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Self-citationActive anaphylaxis in IgE-deficient mice
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Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Xiao, G. G., Wang, M., Li, N., Loo, J. A., & Nel, A. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306423200 · Cited by 428
Public health and components of particulate matter: The changing assessment of black carbon
Grahame, T. J., Klemm, R., & Schlesinger, R. B. (2014) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2014.912692 · Cited by 294
Whitekus, M. J., Li, N., Zhang, M., Wang, M., Horwitz, M. A., Nelson, S. K., Horwitz, L. D., Brechun, N., Diaz-Sanchez, D., & Nel, A. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.5.2560 · Cited by 198
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Metadata
- Authors
- TAKANO, H., YOSHIKAWA, T., ICHINOSE, T., MIYABARA, Y., IMAOKA, K., & SAGAI, M.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-07-01
- Volume
- 156
- Issue
- 1
- Pages
- 36-42
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2127456551
- Cited by
- 441
- References
- 27
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Diesel Exhaust Particles Enhance Antigen-induced Airway Inflammation and Local Cytokine Expression in Mice. https://app.cochat.ai/papers/10.1164/ajrccm.156.1.9610054
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- TAKANO, H., YOSHIKAWA, T., ICHINOSE, T., MIYABARA, Y., IMAOKA, K., & SAGAI, M. (1997). Diesel Exhaust Particles Enhance Antigen-induced Airway Inflammation and Local Cytokine Expression in Mice. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.156.1.9610054
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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