The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Transforming Growth Factor- β 1 in Asthma: Measurement in Bronchoalveolar Lavage Fluid
Abstract
Airway wall remodeling is an established pathological feature in asthma. Its causes are not well understood, but one mediator of potential relevance is transforming growth factor-beta 1 (TGF-beta 1). We have measured levels of immunoreactive TGF-beta 1 in bronchoalveolar lavage (BAL) fluid from clinically stable atopic asthmatics and healthy control subjects. We have also examined the influence of allergen exposure on TGF-beta 1 release in the airways using a segmental bronchoprovocation model, with BAL performed at two time points following endobronchial allergen and sham saline challenges. Basal concentrations of TGF-beta 1 were significantly higher in asthmatics than control subjects (median 8.0 versus 5.5 pg/ml, p = 0.027). Following segmental bronchoprovocation, concentrations of TGF-beta 1 at the allergen- and saline-challenged sites were not significantly different after 10 min, (31.3 versus 25.0 pg/ml, p = 0.78), but after 24 h there were significantly higher TGF-beta 1 concentrations at the allergen-challenged sites (46.0 versus 21.5 pg/ml, p = 0.017). We conclude that basal TGF-beta 1 levels in the airways are elevated in atopic asthma and that these levels increase further in response to allergen exposure. These findings are consistent with the hypothesis that TGF-beta 1 is implicated in airway wall remodeling in asthma.
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Cites
Yamauchi, K., Martinet, Y., Basset, P., Fells, G. A., & Crystal, R. G. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.6.1360 · Cited by 76
Cited by
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Inflammatory Mediators of Asthma: An Update
Barnes, P. J., Chung, K. F., & Page, C. P. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01381-4 · Cited by 717
Chakir, J., Shannon, J., Molet, S., Fukakusa, M., Elias, J., Laviolette, M., Boulet, L.-P., & Hamid, Q. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1557 · Cited by 639
Chung, K. F., & Barnes, P. J. (1999) · Thorax · doi:10.1136/thx.54.9.825 · Cited by 638
Involvement of the epidermal growth factor receptor in epithelial repair in asthma
Puddicombe, S. M., Polosa, R., Richter, A., Krishna, M. T., Howarth, P. H., Holgate, S. T., & Davies, D. E. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.10.1362 · Cited by 531
Self-citation
Metadata
- Authors
- REDINGTON, A. E., MADDEN, J., FREW, A. J., DJUKANOVIC, R., ROCHE, W. R., HOLGATE, S. T., & HOWARTH, P. H.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-08-01
- Volume
- 156
- Issue
- 2
- Pages
- 642-647
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1839043230
- Cited by
- 417
- References
- 1
- FWCI
- 5.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- REDINGTON, A. E., MADDEN, J., FREW, A. J., DJUKANOVIC, R., ROCHE, W. R., HOLGATE, S. T., & HOWARTH, P. H. (1997). Transforming Growth Factor- β 1 in Asthma: Measurement in Bronchoalveolar Lavage Fluid. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.156.2.9605065
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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