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Transforming Growth Factor- β Expression in Mucosal Biopsies in Asthma and Chronic Bronchitis
Abstract
We assessed whether transforming growth factor-beta (TGF-beta), a fibrogenic growth factor, may be involved in remodeling of asthma and chronic bronchitis; its expression was compared with that of epidermal growth factor (EGF) and granulocyte macrophage colony-stimulating factor (GM-CSF) in bronchial mucosal biopsies from 13 normal subjects, 24 asthmatics, and 19 patients with chronic bronchitis. TGF-beta immunoreactivity was highly increased in epithelium and submucosa of those with bronchitis and to a lesser extent in asthmatics. By comparison, with normal subjects, EGF immunoreactivity was significantly increased in the epithelium of bronchitic subjects and submucosa of asthmatics, and, GM-CSF immunoreactivity was increased in both epithelial and submucosal cells of asthmatics and to a lesser extent in submucosa of bronchitics. A significant correlation was found between the number of epithelial or submucosal cells expressing TGF-beta in both asthma and chronic bronchitis and basement membrane thickness and fibroblast number. No such correlation was found for EGF or GM-CSF. in situ hybridization for TGF-beta 1 mRNA confirmed the results obtained by immunohistochemistry. By combining in situ hybridization and immunohistochemistry, it was found that eosinophils and fibroblasts were synthetizing TGF-beta in asthma and bronchitis. These data suggest that TGF-beta, but not EGF or GM-CSF, is involved in airways remodeling in asthma and chronic bronchitis.
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Cited by
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
Self-citationAsthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Self-citationJutel, M., Akdis, M., Budak, F., Aebischer‐Casaulta, C., Wrzyszcz, M., Blaser, K., & Akdis, C. A. (2003) · European Journal of Immunology · doi:10.1002/eji.200322919 · Cited by 915
Inflammation, Growth Factors, and Pulmonary Vascular Remodeling
Hassoun, P. M., Mouthon, L., Barberà, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Maitland, M. L., Michelakis, E. D., Morrell, N. W., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.006 · Cited by 710
Metadata
- Authors
- VIGNOLA, A. M., CHANEZ, P., CHIAPPARA, G., MERENDINO, A., PACE, E., RIZZO, A., la ROCCA, A. M., BELLIA, V., BONSIGNORE, G., & BOUSQUET, J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-08-01
- Volume
- 156
- Issue
- 2
- Pages
- 591-599
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2107792698
- Cited by
- 568
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Transforming Growth Factor- β Expression in Mucosal Biopsies in Asthma and Chronic Bronchitis. https://app.cochat.ai/papers/10.1164/ajrccm.156.2.9609066
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- VIGNOLA, A. M., CHANEZ, P., CHIAPPARA, G., MERENDINO, A., PACE, E., RIZZO, A., la ROCCA, A. M., BELLIA, V., BONSIGNORE, G., & BOUSQUET, J. (1997). Transforming Growth Factor- β Expression in Mucosal Biopsies in Asthma and Chronic Bronchitis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.156.2.9609066
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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