Neutrophils and Protease/Antiprotease Imbalance
Abstract
An imbalance between neutrophil proteases and the surrounding antiproteases is critical in the normal functioning of the neutrophil. Enzyme activity is of importance in cell migration and may play a role in some beneficial aspects of host defense. However, when persistent or excessive this imbalance can be detrimental and (even in the absence of antiprotease deficiency) central to most of the pathogenic processes in COPD. Understanding of these complex relationships that alter a beneficial host defense response to a destructive one will be critical in the development of long-term therapeutic strategies. Stockley RA. Neutrophils and protease/antiprotease imbalance.
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HNE is a causal factor in the progression of emphysema and chronic obstructive pulmonary disease (COPD).
“However, HNE is also a causal factor in the progression of emphysema and chronic obstructive pulmonary disease (COPD) [6,7] due to the enzyme’s propensity to propagate cyclic inflammation, recruit neutrophils, and proteolytically destroy elastic lung tissue [8,9].”
From Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase (2021) · cites this paper as [6]
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References 39 · Cited by 292
- Authors
- STOCKLEY, R. A.
- Affiliations
- Queen Elizabeth Hospital Birmingham (GB)
- Corresponding author
- STOCKLEY, R. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11-01
- Volume
- 160
- Issue
- Supplement_1
- Pages
- S49-S52
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2015688293
- Cited by
- 292
- References
- 39
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 19 · 2021: 9 · 2020: 7 · 2019: 14 · 2018: 13 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 7 · 2013: 13 · 2012: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- neutrophils, protease-antiprotease imbalance, neutrophil proteases, antiproteases, chronic obstructive pulmonary disease, neutrophil migration, host defense, neutrophil elastase, alpha-1-antitrypsin
- MeSH terms
- Humans, Lung Diseases, Obstructive, Protease Inhibitors, Smoking, Leukocyte Elastase, Respiratory Mucosa, Neutrophil Infiltration, Matrix Metalloproteinase 8, Matrix Metalloproteinase Inhibitors
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