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The Macrophage in Chronic Obstructive Pulmonary Disease
Abstract
Macrophages are the predominant defense cell in the normal lung and during conditions associated with chronic inflammation such as COPD. However, the role of the macrophage in the development of COPD has been controversial. Scientific evidence from a variety of sources is emerging that supports a primary role for the macrophage in regulating the inflammatory response and tissue destruction associated with COPD. The role of macrophage proteinases in the development of emphysema, a major component of COPD, will be discussed. Shapiro SD. The macrophage in chronic obstructive pulmonary disease.
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Citations
Cited by
Mediators of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.2 · Cited by 710
Rajendrasozhan, S., Yang, S.-R., Kinnula, V. L., & Rahman, I. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1269oc · Cited by 520
Yang, S.-R., Wright, J., Bauter, M., Seweryniak, K., Kode, A., & Rahman, I. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00308.2006 · Cited by 391
Shaykhiev, R., Krause, A., Salit, J., Strulovici-Barel, Y., Harvey, B.-G., O'Connor, T. P., & Crystal, R. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900473 · Cited by 359
Oxidative Stress in COPD: Sources, Markers, and Potential Mechanisms
McGuinness, A., & Sapey, E. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6020021 · Cited by 243
“In health, macrophages are the most common immune cell found in the peripheral lung [72], where they will regularly encounter environmental ROS, and are key in the resolution of inflammation via efferocytosis of apoptotic neutrophils.”
Background
Metadata
- Authors
- SHAPIRO, S. D.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-11-01
- Volume
- 160
- Issue
- supplement_1
- Pages
- S29-S32
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2044403651
- Cited by
- 322
- References
- 0
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- SHAPIRO, S. D. (1999). The Macrophage in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.160.supplement_1.9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
