The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Impact of Obstructive Sleep Apnea on Left Ventricular Mass and Diastolic Function
Abstract
We wished to determine if obstructive sleep apnea (OSA) is associated with increased left ventricular mass (LVM) and impaired left ventricular diastolic function (LVDF) independently of coexisting obesity, hypertension (HTN), and diabetes mellitus (DM). Patients without primary cardiac disease, referred for evaluation of OSA (n = 533), had overnight polysomnography and Doppler echocardiography while awake. Patients were divided, according to the apnea–hypopnea index (AHI), into an OSA group (AHI ⩾ 5/h, n = 353) and a non-OSA group (AHI < 5/h, n = 180). In men, LVM was greater in the OSA group (98.9 ± 25.6 versus 92.3 ± 22.5 g/m, p = 0.023) despite exclusion of those with HTN and DM. A similar trend was noted in women. Regression analysis revealed that LVM was correlated with body mass index (BMI) (β = 0.480, p < 0.0005), age (β = 0.16, p = 0.001), and the presence of HTN (β = 0.137, p = 0.003) in men and with BMI (β = 0.501, p < 0.0005) in women, but not with AHI or oxygen saturation during sleep. The ratio of peak early filling velocity to peak late filling velocity (E/A), an index of LVDF, was similar in both groups (1.28 ± 0.32 versus 1.34 ± 0.31, p = 0.058); it was correlated with age (β = − 0.474, p < 0.0005), but not with AHI or oxygen saturation during sleep. We conclude that OSA is not associated with increased LVM or impaired LVDF independently of obesity, HTN, or advancing age.
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“Although some studies have failed to show a relationship between sleep apnea and LV hypertrophy, the majority do support such an association (18, 22, 69, 250, 256–258, 284, 287, 331, 373).”
From Cardiac remodeling in obesity (2008) · cites this paper as [256]
Citations
Cites
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Effect of Intrathoracic Pressure on Left Ventricular Performance
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Snoring and Sleep Apnea. A Population Study in Australian Men
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Research works printed but not linked: 2
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- Coccagna, 1972, Continuous recordings of pulmonary and arterial pressure during sleep in syndromes of hypersomnolence with periodic breathing., Bull Eur Physiopath Respir, 8, 1159
Cited by
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Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Obstructive sleep apnoea and its cardiovascular consequences
Bradley, T. D., & Floras, J. S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61622-0 · Cited by 1,385
Obstructive Sleep Apnea, Obesity, and the Risk of Incident Atrial Fibrillation
Gami, A. S., Hodge, D. O., Herges, R. M., Olson, E. J., Nykodym, J., Kara, T., & Somers, V. K. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.060 · Cited by 1,104
McNicholas, W. T., Bonsignore, M. R., & the Management Committee of EU COST ACTION B26 (2007) · European Respiratory Journal · doi:10.1183/09031936.00027406 · Cited by 911
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Metadata
- Authors
- NIROUMAND, M., KUPERSTEIN, R., SASSON, Z., & HANLY, P. J.
- Affiliations
- St. Michael's Hospital (CA)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06-01
- Volume
- 163
- Issue
- 7
- Pages
- 1632-1636
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2020713898
- Cited by
- 156
- References
- 32
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 8 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 10 · 2015: 12 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obstructive sleep apnea, left ventricular mass, left ventricular diastolic function, apnea-hypopnea index, obesity, hypertension, diabetes mellitus, body mass index, E/A ratio, cardiac remodeling
- MeSH terms
- Adult, Cardiovascular Diseases, Diastole, Echocardiography, Female, Heart Ventricles, Humans, Male, Middle Aged, Risk Factors, Body Mass Index, Ventricular Function, Left, Hypertrophy, Left Ventricular, Sleep Apnea, Obstructive
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