The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Diagnostic Value of Procalcitonin, Interleukin-6, and Interleukin-8 in Critically Ill Patients Admitted with Suspected Sepsis
Open accessAbstract
To assess the diagnostic value of procalcitonin (PCT), interleukin (IL)-6, IL-8, and standard measurements in identifying critically ill patients with sepsis, we performed prospective measurements in 78 consecutive patients admitted with acute systemic inflammatory response syndrome (SIRS) and suspected infection. We estimated the relevance of the different parameters by using multivariable regression modeling, likelihood-ratio tests, and area under the receiver operating characteristic curves (AUC). The final diagnosis was SIRS in 18 patients, sepsis in 14, severe sepsis in 21, and septic shock in 25. PCT yielded the highest discriminative value, with an AUC of 0.92 (CI, 0.85 to 1.0), followed by IL-6 (0.75; CI, 0.63 to 0.87), and IL-8 (0.71; CI, 0.59 to 0.83; p < 0.001). At a cutoff of 1.1 ng/ml, PCT yielded a sensitivity of 97% and a specificity of 78% to differentiate patients with SIRS from those with sepsis-related conditions. Median PCT concentrations on admission (ng/ ml, range) were 0.6 (0 to 5.3) for SIRS; 3.5 (0.4 to 6.7) for sepsis; 6.2 (2.2 to 85) for severe sepsis; and 21.3 (1.2 to 654) for septic shock (p < 0.001). The addition of PCT to a model based solely on standard indicators improved the predictive power of detecting sepsis (likelihood ratio test; p = 0.001) and increased the AUC value for the routine value-based model from 0.77 (CI, 0.64 to 0.89) to 0.94 (CI, 0.89 to 0.99; p = 0.002). In contrast, no additive effect was seen for IL-6 (p = 0.56) or IL-8 (p = 0.14). Elevated PCT concentrations appear to be a promising indicator of sepsis in newly admitted, critically ill patients capable of complementing clinical signs and routine laboratory parameters suggestive of severe infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Empirical evidence of design-related bias in studies of diagnostic tests.
Lijmer, J. G. (1999) · JAMA · doi:10.1001/jama.282.11.1061 · Cited by 1,861
Cited by
Procalcitonin as a diagnostic marker for sepsis: A systematic review and meta-analysis.
Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70323-7 · Cited by 1,198
Bouadma, L., Luyt, C.-E., Tubach, F., Cracco, C., Alvarez, A., Schwebel, C., Schortgen, F., Lasocki, S., Veber, B., Dehoux, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61879-1 · Cited by 1,183
de Jong, E., van Oers, J. A., Beishuizen, A., Vos, P., Vermeijden, W. J., Haas, L. E., Loef, B. G., Dormans, T., van Melsen, G. C., Kluiters, Y. C., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00053-0 · Cited by 836
Use of Procalcitonin to Shorten Antibiotic Treatment Duration in Septic Patients
Nobre, V., Harbarth, S., Graf, J.-D., Rohner, P., & Pugin, J. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1238oc · Cited by 605
Self-citationJensen, J. U., Hein, L., Lundgren, B., Bestle, M. H., Mohr, T. T., Andersen, M. H., Thornberg, K. J., Løken, J., Steensen, M., Fox, Z., et al. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31821e8791 · Cited by 356
Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study
Stolz, D., Smyrnios, N., Eggimann, P., Pargger, H., Thakkar, N., Siegemund, M., Marsch, S., Azzola, A., Rakic, J., Mueller, B., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00053209 · Cited by 327
Hochreiter, M., Köhler, T., Schweiger, A. M., Keck, F. S., Bein, B., von Spiegel, T., & Schroeder, S. (2009) · Critical Care · doi:10.1186/cc7903 · Cited by 315
Bloos, F., Trips, E., Nierhaus, A., Briegel, J., Heyland, D. K., Jaschinski, U., Moerer, O., Weyland, A., Marx, G., Gründling, M., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.2514 · Cited by 268
Schroeder, S., Hochreiter, M., Koehler, T., Schweiger, A.-M., Bein, B., Keck, F. S., & von Spiegel, T. (2009) · Langenbeck's Archives of Surgery · doi:10.1007/s00423-008-0432-1 · Cited by 238
Martínez-García, J. J., Martínez-Banaclocha, H., Angosto-Bazarra, D., de Torre-Minguela, C., Baroja-Mazo, A., Alarcón-Vila, C., Martínez-Alarcón, L., Amores-Iniesta, J., Martín-Sánchez, F., Ercole, G. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10626-x · Cited by 233
Forty years of calcitonin—where are we now? A tribute to the work of Iain Macintyre, FRS
Zaidi, M., Inzerillo, A. M., Moonga, B. S., Bevis, P. J. R., & Huang, C. L.-H. (2002) · Bone · doi:10.1016/s8756-3282(02)00688-9 · Cited by 151
The Captain Study Group, Parlato, M., Philippart, F., Rouquette, A., Moucadel, V., Puchois, V., Blein, S., Bedos, J.-P., Diehl, J.-L., Hamzaoui, O., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5228-3 · Cited by 85
Metadata
- Authors
- HARBARTH, S., HOLECKOVA, K., FROIDEVAUX, C., PITTET, D., RICOU, B., GRAU, G. E., VADAS, L., PUGIN, J., & the Geneva Sepsis Network
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08-01
- Volume
- 164
- Issue
- 3
- Pages
- 396-402
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2152955526
- Cited by
- 898
- References
- 2
- FWCI
- 16.64
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
