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Cited by 187Allergic Rhinitis and SensitizationIndoor Air Quality and Microbial ExposureAsthma and respiratory diseases

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Antigenic Analysis of Household Dust Samples

Wood, Robert A., Eggleston, Peyton A., Lind, Peter, Ingemann, Lars, Schwartz, Bente, Graveson, Suzanne, Terry, David, Wheeler, Barbara, Adkinson, N. Franklin·1988·American Review of Respiratory Disease
DOI 10.1164/ajrccm/137.2.358
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Abstract

Household dust samples from the homes of 106 allergy clinic patients in Baltimore were analyzed for specific allergen content. Dust mite antigen content was determined by enzyme-linked immunosorbent assays (ELISA) specific for the major allergens of Dermatophagoides pteronyssinus, D. farinae, and D. microceras. Cat and dog antigen content were determined by ELISA using antisera for Fel d 1 (formerly cat allergen 1) and dog allergens 3 and 13, respectively. Mold content was assessed by culture with microscopic identification. Dust mite antigen was detected in 99% of homes (D. farinae, 95%; D. pteronyssinus, 88%; D. microceras, 31%), with total antigen content ranging from 50 ng/g dust (the lower limit of detection) to 30,170 ng/g (median, 1,123 ng/g). Animal allergens were found in 100% of samples (cat: range, 2 to 130,000 ng Fel d 1/g; median, 90 ng/g; dog: range, 112.5 to 585,000 IU/g; median, 2,719.5 IU/g). Although there were highly significant differences in antigen content (p < 0.001) between homes with and without a particular pet in residence, many homes without pets contained pet allergens at high concentrations. Molds were also detected in 100% of homes (range, 4 to 761 colonies/30 mg dust; median, 72 colonies/30 mg). No correlation was demonstrated between antigen content and skin test results, a history of asthma, symptoms on allergen exposure, or the age of the home (except for molds) for any of the allergens detected. We conclude that dust mite allergens, cat and dog allergens, and molds are virtually ubiquitous in Baltimore homes and that our ability to predict the presence and relative quantities of these allergens on clinical grounds is very limited.

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Crossref · 10.1164/ajrccm/137.2.358

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Metadata

Authors
Wood, R. A., Eggleston, P. A., Lind, P., Ingemann, L., Schwartz, B., Graveson, S., Terry, D., Wheeler, B., & Adkinson, N. F.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
American Review of Respiratory Disease
Publisher
Oxford University Press (OUP)
Published
1988-02-01
Volume
137
Issue
2
Pages
358-363
ISSN
0003-0805 (ISSN-L)
DOI
10.1164/ajrccm/137.2.358
OpenAlex
W2080585191
Cited by
187
References
7
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2019: 2 · 2016: 5 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Review of Respiratory Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (AI 21073)
  • National Center for Research Resources (RR 00035)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords
house dust, indoor allergens, house dust mite allergens, Dermatophagoides farinae, Dermatophagoides pteronyssinus, Fel d 1, dog allergen, house dust mites, molds, pet allergens, allergen exposure, allergy clinic patients, skin test reactivity, asthma
MeSH terms
Adolescent, Adult, Aged, Allergens, Animals, Antigens, Antigens, Fungal, Asthma, Cats, Child, Child, Preschool, Dogs, Dust, Eczema, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged, Mites, Rhinitis, Skin Tests

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