The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Airways Inflammation in Nocturnal Asthma
Abstract
Nocturnal asthma is a frequent problem, but the mechanism is unclear. We investigated the possibility that airways inflammation occurred during the night. Bronchoalveolar lavage fluid was analyzed in asthmatic patients with (n = 7) and without nocturnal asthma (n = 7) at 1600 and 0400 h. The nocturnal asthma group had an increase in the total leukocyte count (24.0 +/- 7.0 to 41.1 +/- 9.9 x 10(4) cells/ml, p less than 0.05), neutrophils (1.1 +/- 0.6 to 3.7 +/- 1.5 x 10(4) cells/ml, p less than 0.05), and eosinophils (0.5 +/- 0.1 to 1.7 +/- 0.7 x 10(4) cells/ml, p less than 0.05) from 1600 to 0400 h. Cellular components for the non-nocturnal asthma group did not change. Between groups, the 1600-h cells were similar. At 0400 h the nocturnal asthma group had significantly higher total leukocyte, neutrophil, eosinophil, lymphocyte, and epithelial cell counts. For all subjects, the overnight fall in peak expiratory flow rates was correlated to the change in neutrophils (r = 0.54, p less than 0.05) and eosinophils (r = 0.77, p less than 0.05). We conclude that the nocturnal worsening of asthma has an associated cellular inflammatory response that is not seen in patients without overnight decrements in lung function. This inflammatory response together with epithelial damage may be important factors in the etiology of nocturnal asthma.
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Cites
Damage of the Airway Epithelium and Bronchial Reactivity in Patients with Asthma
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Asthma: analysis of sudden deaths and ventilatory arrests in hospital.
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Bronchoalveolar Lavage of Allergic Asthmatic Patients following Allergen Bronchoprovocation
Metzger, W. J., Richerson, H. B., Worden, K., Monick, M., & Hunninghake, G. W. (1986) · Chest · doi:10.1378/chest.89.4.477 · Cited by 273
Burrows, B. (1975) · Chest · doi:10.1378/chest.67.5.583 · Cited by 273
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Factors Related to the Nocturnal Worsening of Asthma
Martin, R. J., Cicutto, L. C., & Ballard, R. D. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.33 · Cited by 158
Self-citationTwenty-four-hour rhythm in the bronchial hyperreactivity to house dust in asthmatics
Gervais, P., Reinberg, A., Gervais, C., Smolensky, M. H., & Defrance, O. (1977) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(77)90151-8 · Cited by 91
Effects of granulocyte depletion on pulmonary responsiveness to aerosol histamine
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Cited by
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Alveolar tissue inflammation in asthma.
Kraft, M., Djukanovic, R., Wilson, S., Holgate, S. T., & Martin, R. J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.5.8912772 · Cited by 573
Self-citationOxidative and nitrosative events in asthma
Andreadis, A. A., Hazen, S. L., Comhair, S. A. A., & Erzurum, S. C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00278-8 · Cited by 327
Metadata
- Authors
- Martin, R. J., Cicutto, L. C., Smith, H. R., Ballard, R. D., & Szefler, S. J.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-02
- Volume
- 143
- Issue
- 2
- Pages
- 351-357
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W2079336364
- Cited by
- 294
- References
- 10
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Martin, R. J., Cicutto, L. C., Smith, H. R., Ballard, R. D., & Szefler, S. J. (1991). Airways Inflammation in Nocturnal Asthma. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/143.2.351
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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