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The Induction of Pulmonary Emphysema with Human Leukocyte Elastase 1– 3
Abstract
Purified human leukocyte elastase was injected into the tracheas of 46 hamsters. Thirteen animals died spontaneously within 1 week, with extensive lung hemorrhage. The elastin content of the lungs was only slightly less than control values 3 hours after injection. At 2 months, the lungs of the remaining animals showed mild, patchy emphysema and morphometric changes consistent with emphysema. These results contrasted with the effects of a similar elastolytic dose of pancreatic elastase administered to 26 other hamsters in that only one animal died spontaneously, the lung elastin content 3 hours after injection was substantially decreased, and severe emphysema was present 2 months later. Leukocyte elastase appears to be capable of causing emphysema; but unlike pancreatic elastase, leukocyte elastase produces emphysema that is mild, even at a dose sufficient to produce intense lung hemorrhage and a high mortality.
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Citations
Cited by
Macrophages and Polymorphonuclear Neutrophils in Lung Defense and Injury
Sibille, Y., & Reynolds, H. Y. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.2.471 · Cited by 1,083
Mediators of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.2 · Cited by 710
Replacement Therapy for Alpha1-Antitrypsin Deficiency Associated with Emphysema
Wewers, M. D., Casolaro, M. A., Sellers, S. E., Swayze, S. C., McPhaul, K. M., Wittes, J. T., & Crystal, R. G. (1987) · New England Journal of Medicine · doi:10.1056/nejm198704233161704 · Cited by 641
Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung
Genschmer, K. R., Russell, D. W., Lal, C., Szul, T., Bratcher, P. E., Noerager, B. D., Abdul Roda, M., Xu, X., Rezonzew, G., Viera, L., et al. (2019) · Cell · doi:10.1016/j.cell.2018.12.002 · Cited by 445
The role of neutrophil elastase in acute lung injury
Kawabata, K., Hagio, T., & Matsuoka, S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02182-9 · Cited by 337
Metadata
- Authors
- Senior, R. M., Tegner, H., Kuhn, C., Ohlsson, K., Starcher, B. C., & Pierce, J. A.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1977-09
- Volume
- 116
- Issue
- 3
- Pages
- 469-475
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W1983344336
- Cited by
- 339
- References
- 0
- FWCI
- 13.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Senior, R. M., Tegner, H., Kuhn, C., Ohlsson, K., Starcher, B. C., & Pierce, J. A. (1977). The Induction of Pulmonary Emphysema with Human Leukocyte Elastase 1– 3. American Review of Respiratory Disease. https://doi.org/10.1164/arrd.1977.116.3.469
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
