Immunologic and Hemodynamic Effects of “Low-Dose” Hydrocortisone in Septic Shock: A Double-Blind, Randomized, Placebo-controlled, Crossover Study

Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy. To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in…