The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Pigment Epithelium–derived Factor in Idiopathic Pulmonary Fibrosis: A Role in Aberrant Angiogenesis
Abstract
Pigment epithelium-derived factor (PEDF) is a 50-kD protein with angiostatic and neurotrophic activities that regulates vascular development within the eye. PEDF expression was increased in the lungs of patients with idiopathic pulmonary fibrosis (IPF) based on microarray analyses. Angiogenesis has been implicated in the pathogenesis of fibrotic lung diseases, we therefore hypothesized that regional abnormalities in vascularization occur in IPF as a result of an imbalance between PEDF and vascular endothelial growth factor. We demonstrated that vascular density is regionally decreased in IPF within the fibroblastic foci, and that within these areas PEDF was increased, whereas vascular endothelial growth factor was decreased. PEDF colocalized with the fibrogenic cytokine, transforming growth factor (TGF)-beta 1, particularly within the fibrotic interstitium and the fibroblastic focus, and prominently within the epithelium directly overlying the fibroblastic focus. This suggested that TGF-beta 1 might regulate PEDF expression. Using 3T3-L1 fibroblasts and human lung fibroblasts, we showed that PEDF was indeed a TGF-beta 1 target gene. Collectively, our findings implicate PEDF as a regulator of pulmonary angiogenesis and an important mediator in IPF.
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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,117
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Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
Dawson, D. W., Volpert, O. V., Gillis, P., Crawford, S. E., Xu, H.-J., Benedict, W., & Bouck, N. P. (1999) · Science · doi:10.1126/science.285.5425.245 · Cited by 1,505
Tonnesen, M. G., Feng, X., & Clark, R. A. F. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00014.x · Cited by 1,463
Idiopathic Pulmonary Fibrosis: Clinical Relevance of Pathologic Classification
KATZENSTEIN, A.-L. A., & MYERS, J. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707039 · Cited by 1,261
Inhibition of VEGF receptors causes lung cell apoptosis and emphysema
Kasahara, Y., Tuder, R. M., Taraseviciene-Stewart, L., Le Cras, T. D., Abman, S., Hirth, P. K., Waltenberger, J., & Voelkel, N. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10259 · Cited by 1,112
Predicting Survival in Idiopathic Pulmonary Fibrosis
KING, T. E., TOOZE, J. A., SCHWARZ, M. I., BROWN, K. R., & CHERNIACK, R. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.7.2003140 · Cited by 853
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King, T. E., Pardo, A., & Selman, M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60052-4 · Cited by 2,194
Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
Wollin, L., Wex, E., Pautsch, A., Schnapp, G., Hostettler, K. E., Stowasser, S., & Kolb, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00174914 · Cited by 1,005
Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis
Chaudhary, N. I., Roth, G. J., Hilberg, F., Müller-Quernheim, J., Prasse, A., Zissel, G., Schnapp, A., & Park, J. E. (2007) · European Respiratory Journal · doi:10.1183/09031936.00152106 · Cited by 386
Idiopathic Pulmonary Fibrosis (IPF): An Overview
Barratt, S., Creamer, A., Hayton, C., & Chaudhuri, N. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7080201 · Cited by 382
Jacob, J., Bartholmai, B. J., Rajagopalan, S., Kokosi, M., Nair, A., Karwoski, R., Walsh, S. L. F., Wells, A. U., & Hansell, D. M. (2017) · European Respiratory Journal · doi:10.1183/13993003.01011-2016 · Cited by 309
Metadata
- Authors
- Cosgrove, G. P., Brown, K. K., Schiemann, W. P., Serls, A. E., Parr, J. E., Geraci, M. W., Schwarz, M. I., Cool, C. D., & Worthen, G. S.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08-01
- Volume
- 170
- Issue
- 3
- Pages
- 242-251
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1922000778
- Cited by
- 253
- References
- 64
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Pigment Epithelium–derived Factor in Idiopathic Pulmonary Fibrosis: A Role in Aberrant Angiogenesis. https://app.cochat.ai/papers/10.1164/rccm.200308-1151oc
- The paper
- Cosgrove, G. P., Brown, K. K., Schiemann, W. P., Serls, A. E., Parr, J. E., Geraci, M. W., Schwarz, M. I., Cool, C. D., & Worthen, G. S. (2004). Pigment Epithelium–derived Factor in Idiopathic Pulmonary Fibrosis: A Role in Aberrant Angiogenesis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200308-1151oc
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
