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Alternative Methods of Titrating Continuous Positive Airway Pressure: A Large Multicenter Study

Masa, Juan F., Jiménez, Antonio, Durán, Joaquín, Capote, Francisco, Monasterio, Carmen, Mayos, Mercedes, Terán, Joaquín, Hernández, Lourdes, Barbé, Ferrán, Maimó, Andrés, Rubio, Manuela, Montserrat, José M.·2004·American Journal of Respiratory and Critical Care Medicine

Abstract

Standard practice for continuous positive airway pressure (CPAP) treatment in sleep apnea and hypopnea syndrome (SAHS) requires pressure titration during attended laboratory polysomnography. However, polysomnographic titration is expensive and time-consuming. The aim of this study was to ascertain, in a large sample of CPAP-naive patients, whether CPAP titration performed by an unattended domiciliary autoadjusted CPAP device or with a predicted formula was as effective as CPAP titration performed by full polysomnography. The main outcomes were the apnea-hypopnea index and the subjective daytime sleepiness. We included 360 patients with SAHS requiring CPAP treatment. Patients were randomly allocated into three groups: standard, autoadjusted, and predicted formula titration with domiciliary adjustment. The follow-up period was 12 weeks. With CPAP treatment, the improvement in subjective sleepiness and apnea-hypopnea index was very similar in the three groups. There were no differences in the objective compliance of CPAP treatment and in the dropout rate of the three groups at the end of the follow-up. Autoadjusted titration at home and predicted formula titration with domiciliary adjustment can replace standard titration. These procedures could lead to considerable savings in cost and to significant reductions in the waiting list.

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Metadata

Authors
Masa, J. F., Jiménez, A., Durán, J., Capote, F., Monasterio, C., Mayos, M., Terán, J., Hernández, L., Barbé, F., Maimó, A., Rubio, M., & Montserrat, J. M.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
2004-12-01
Volume
170
Issue
11
Pages
1218-1224
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W2113932992
Cited by
328
References
6
FWCI
10.83
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Alternative Methods of Titrating Continuous Positive Airway Pressure: A Large Multicenter Study. https://app.cochat.ai/papers/10.1164/rccm.200312-1787oc
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Masa, J. F., Jiménez, A., Durán, J., Capote, F., Monasterio, C., Mayos, M., Terán, J., Hernández, L., Barbé, F., Maimó, A., Rubio, M., & Montserrat, J. M. (2004). Alternative Methods of Titrating Continuous Positive Airway Pressure: A Large Multicenter Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200312-1787oc

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