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Cited by 543

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease

Dahl, Morten, Vestbo, Jørgen, Lange, Peter, Bojesen, Stig E., Tybjærg-Hansen, Anne, Nordestgaard, Børge G.·2007·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200605-713oc
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Abstract

RATIONALE: Patients with chronic obstructive pulmonary disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring serum C-reactive protein (CRP). OBJECTIVE: To determine whether increased serum CRP in individuals with airway obstruction predicts future hospitalization and death from COPD. METHODS: We performed a cohort study with a median of 8-yr follow-up of 1,302 individuals with airway obstruction selected from the ongoing Copenhagen City Heart Study. MEASUREMENTS AND MAIN RESULTS: We measured serum CRP at baseline, and recorded COPD admissions and deaths as outcomes. During follow-up, 185 (14%) individuals were hospitalized due to COPD and 83 (6%) died of COPD. Incidences of COPD hospitalization and COPD death were increased in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L (log rank: p < 0.001). After adjusting for sex, age, FEV(1)% predicted, tobacco consumption, and ischemic heart disease, the hazard ratios for hospitalization and death due to COPD were increased at 1.4 (95% confidence interval, 1.0-2.0) and 2.2 (1.2-3.9) in individuals with baseline CRP > 3 mg/L versus < or = 3 mg/L. After close matching for FEV(1)% predicted and adjusting for potential confounders, baseline CRP was, on average, increased by 1.2 mg/L (analysis of variance: p = 0.002) and 4.1 mg/L (p = 0.001) in those who were subsequently hospitalized or died of COPD, respectively. The absolute 10-yr risks for COPD hospitalization and death in individuals with CRP above 3 mg/L were 54 and 57%, respectively, among those older than 70 yr with a tobacco consumption above 15 g/d and an FEV(1)% predicted of less than 50. CONCLUSIONS: CRP is a strong and independent predictor of future COPD outcomes in individuals with airway obstruction.

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Metadata

Authors
Dahl, M., Vestbo, J., Lange, P., Bojesen, S. E., Tybjærg-Hansen, A., & Nordestgaard, B. G.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2007-02-01
Volume
175
Issue
3
Pages
250-255
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200605-713oc
OpenAlex
W1991265445
Cited by
543
References
46
FWCI
32.20
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/rccm.200605-713oc
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Dahl, M., Vestbo, J., Lange, P., Bojesen, S. E., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2007). C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200605-713oc

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.