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Cited by 328Respiratory Support and MechanismsNeonatal Respiratory Health ResearchAirway Management and Intubation Techniques

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

Recruitment Maneuvers for Acute Lung Injury

Fan, Eddy, Wilcox, M. Elizabeth, Brower, Roy G., Stewart, Thomas E., Mehta, Sangeeta, Lapinsky, Stephen E., Meade, Maureen O., Ferguson, Niall D.·2008·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.200802-335oc
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Abstract

Rationale: There are conflicting data regarding the safety and efficacy of recruitment maneuvers (RMs) in patients with acute lung injury (ALI). Objectives: To summarize the physiologic effects and adverse events in adult patients with ALI receiving RMs. Methods>: Systematic review of case series, observational studies, and randomized clinical trials with pooling of study-level data. Measurements and Main Results: Forty studies (1,185 patients) met inclusion criteria. Oxygenation (31 studies; 636 patients) was significantly increased after an RM (PaO2: 106 versus 193 mm Hg, P = 0.001; and PaO2/FiO2 ratio: 139 versus 251 mm Hg, P < 0.001). There were no persistent, clinically significant changes in hemodynamic parameters after an RM. Ventilatory parameters (32 studies; 548 patients) were not significantly altered by an RM, except for higher PEEP post-RM (11 versus 16 cm H2O; P = 0.02). Hypotension (12%) and desaturation (9%) were the most common adverse events (31 studies; 985 patients). Serious adverse events (e.g., barotrauma [1%] and arrhythmias [1%]) were infrequent. Only 10 (1%) patients had their RMs terminated prematurely due to adverse events. Conclusions: Adult patients with ALI receiving RMs experienced a significant increase in oxygenation, with few serious adverse events. Transient hypotension and desaturation during RMs is common but is self-limited without serious short-term sequelae. Given the uncertain benefit of transient oxygenation improvements in patients with ALI and the lack of information on their influence on clinical outcomes, the routine use of RMs cannot be recommended or discouraged at this time. RMs should be considered for use on an individualized basis in patients with ALI who have life-threatening hypoxemia.

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Crossref · 10.1164/rccm.200802-335oc

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Research works printed but not linked: 10

  1. 2005, Crit Care, 9, 60
  2. 2003, Eur Respir J Suppl, 42, 48S
  3. 2003, Crit Care Med, 32, 2371
  4. 2002, Chuirg, 73, 353
  5. 2003, Anaesthesiol Reanim, 28, 8
  6. 1999, Intensive Care Med, 25, 1297, 10.1007/s001340051061 · DOI
  7. 2006, Chin Crit Care Med, 18, 355
  8. 2006, Chin J Surg, 44, 889
  9. 2007, Chin Crit Care Med, 19, 539
  10. 2006, Contemporary Crit Care, 4, 1

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Metadata

Authors
Fan, E., Wilcox, M. E., Brower, R. G., Stewart, T. E., Mehta, S., Lapinsky, S. E., Meade, M. O., & Ferguson, N. D.
Affiliations
  • Johns Hopkins University (US)
  • University of Toronto (CA)
  • McMaster University (CA)
  • University Health Network (CA)
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2008-12-01
Volume
178
Issue
11
Pages
1156-1163
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.200802-335oc
OpenAlex
W1940579175
Cited by
328
References
62
Citations by year
2026: 4 · 2025: 5 · 2024: 9 · 2023: 13 · 2022: 17 · 2021: 15 · 2020: 12 · 2019: 8 · 2018: 12 · 2017: 28 · 2016: 21 · 2015: 29 · 2014: 18 · 2013: 30 · 2012: 28
FWCI
24.27
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
Keywords
recruitment maneuvers, acute lung injury, positive end-expiratory pressure, oxygenation, PaO2/FiO2 ratio, hypotension, desaturation, barotrauma, cardiac arrhythmias, mechanical ventilation, hypoxemia
MeSH terms
Adult, Female, Hemodynamics, Humans, Male, Middle Aged, Oxygen, Respiration, Artificial, Respiratory Function Tests, Acute Lung Injury

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