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Cigarette Smoke–induced Oxidative Stress: A Role in Chronic Obstructive Pulmonary Disease Skeletal Muscle Dysfunction
Abstract
Rationale Inflammation and oxidative stress contribute to muscle dysfunction in patients with chronic obstructive pulmonary disease (COPD). Oxidants contained in cigarette smoke (CS) induce adverse effects on tissues through oxidative phenomena. Objectives To explore oxidative stress and inflammation in quadriceps of human smokers and in diaphragm and limb muscles of guinea pigs chronically exposed to CS. Methods Muscle function, protein oxidation and nitration, antioxidants, oxidized proteins, inflammation, creatine kinase activity, and lung and muscle structures were investigated in vastus lateralis of smokers, patients with COPD, and healthy control subjects and in diaphragm and gastrocnemius of CS-exposed guinea pigs at 3, 4, and 6 months. Measurements and main results Compared with control subjects, quadriceps muscle force was mildly but significantly reduced in smokers; protein oxidation levels were increased in quadriceps of smokers and patients with COPD, and in respiratory and limb muscles of CS-exposed animals; glycolytic enzymes, creatine kinase, carbonic anydrase-3, and contractile proteins were significantly more carbonylated in quadriceps of smokers and patients with COPD, and in respiratory and limb muscles of CS-exposed guinea pigs. Chronic CS exposure induced no significant rise in muscle inflammation in either smokers or rodents. Muscle creatine kinase activity was reduced only in patients with COPD and in both diaphragm and gastrocnemius of CS-exposed anima…
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“Of note, some studies report no difference in oxidative stress markers between COPD patients and healthy smokers [130], implying that oxidative stress could mainly be attributed to CS extracts and not the specificity of systemic involvement of COPD.”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [130]
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“In our results, the number of cigarettes per day was positively correlated with the ferroptosis potential index in LUAD, which may be because the cigarette-induced oxidation reaction promoted lipid peroxidation (Barreiro et al., 2010; Guan et al., 2013; Louhelainen et al., 2008).”
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Metadata
- Authors
- Barreiro, E., Peinado, V. I., Galdiz, J. B., Ferrer, E., Marin-Corral, J., Sánchez, F., Gea, J., & Barberà, J. A.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Instituto de Salud Carlos III (ES)
- Pulmonology Department and Research Unit, Hospital de Cruces, Basque Country University, Barakaldo, Basque Country, Spain
- Muscle and Respiratory System Research Unit, Pulmonology Department, Municipal Institute of Medical Research, Hospital del Mar, and Health and Experimental Sciences Department, Universitat Pompeu Fabra, Barcelona, Catalonia
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08
- Volume
- 182
- Issue
- 4
- Pages
- 477-488
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1941094264
- Cited by
- 272
- References
- 0
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 9 · 2023: 19 · 2022: 15 · 2021: 21 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 21 · 2016: 23 · 2015: 20 · 2014: 20 · 2013: 27 · 2012: 23
- FWCI
- 17.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- cigarette smoke, oxidative stress, chronic obstructive pulmonary disease, skeletal muscle dysfunction, protein oxidation, nitration, muscle inflammation, creatine kinase, diaphragm, quadriceps, guinea pig model, muscle atrophy
- MeSH terms
- Animals, Creatine Kinase, Guinea Pigs, Humans, Lung, Male, Middle Aged, Smoking, Time Factors, Immunoblotting, Biomarkers, Cytokines, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Muscle Weakness, Carbonic Anhydrase III, Reactive Nitrogen Species, Pulmonary Disease, Chronic Obstructive
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