The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Chronic Obstructive Pulmonary Disease Phenotypes: The Future of COPD
Open accessAbstract
Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary disease (COPD). Although FEV(1) inadequately describes this heterogeneity, a clear alternative has not emerged. The goal of phenotyping is to identify patient groups with unique prognostic or therapeutic characteristics, but significant variation and confusion surrounds use of the term "phenotype" in COPD. Phenotype classically refers to any observable characteristic of an organism, and up until now, multiple disease characteristics have been termed COPD phenotypes. We, however, propose the following variation on this definition: "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)." This more focused definition allows for classification of patients into distinct prognostic and therapeutic subgroups for both clinical and research purposes. Ideally, individuals sharing a unique phenotype would also ultimately be determined to have a similar underlying biologic or physiologic mechanism(s) to guide the development of therapy where possible. It follows that any proposed phenotype, whether defined by symptoms, radiography, physiology, or cellular or molecular fingerprint will require an iterative validation process in which "candidate" phenotypes are identified before their relevance to clinical outcome is determined. Although this schema represents an ideal construct, we acknowledge any phenotype may be etiologically heterogeneous and that any one individual may manifest multiple phenotypes. We have much yet to learn, but establishing a common language for future research will facilitate our understanding and management of the complexity implicit to this disease.
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Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Self-citationRabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925
Self-citationCelli, B. R., Cote, C. G., Marin, J. M., Casanova, C., Montes de Oca, M., Mendez, R. A., Pinto Plata, V., & Cabral, H. J. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa021322 · Cited by 4,015
Self-citationA randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema
(2003) · New England Journal of Medicine · doi:10.1056/nejmoa030287 · Cited by 2,071
Casanova, C., Cote, C., de Torres, J. P., Aguirre-Jaime, A., Marin, J. M., Pinto-Plata, V., & Celli, B. R. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-867oc · Cited by 597
Self-citationO'DONNELL, D. E., LAM, M., & WEBB, K. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.2.9901038 · Cited by 485
Hurst, J. R., Perera, W. R., Wilkinson, T. M. A., Donaldson, G. C., & Wedzicha, J. A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200505-704oc · Cited by 346
Cited by
Characterisation of COPD heterogeneity in the ECLIPSE cohort
the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Agusti, A., Calverley, P. M., Celli, B., Coxson, H. O., Edwards, L. D., Lomas, D. A., MacNee, W., Miller, B. E., Rennard, S., et al. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-122 · Cited by 1,157
Self-citationSIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
Yao, H., Chung, S., Hwang, J.-W., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60132 · Cited by 358
Phenotypes in obstructive sleep apnea: A definition, examples and evolution of approaches
Zinchuk, A. V., Gentry, M. J., Concato, J., & Yaggi, H. K. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.10.002 · Cited by 350
Guía Española de la EPOC (GesEPOC). Tratamiento farmacológico de la EPOC estable
Miravitlles, M., Soler-Cataluña, J. J., Calle, M., Molina, J., Almagro, P., Quintano, J. A., Riesco, J. A., Trigueros, J. A., Piñera, P., Simón, A., et al. (2012) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2012.04.001 · Cited by 257
Jeong, S., Park, S. A., Park, I., Kim, P., Cho, N. H., Hyun, J. W., & Hyun, Y.-M. (2019) · Journal of Immunology Research · doi:10.1155/2019/3486841 · Cited by 64
Metadata
- Authors
- Han, M. K., Agusti, A., Calverley, P. M., Celli, B. R., Criner, G., Curtis, J. L., Fabbri, L. M., Goldin, J. G., Jones, P. W., MacNee, W., Make, B. J., Rabe, K. F., Rennard, S. I., Sciurba, F. C., Silverman, E. K., Vestbo, J., Washko, G. R., Wouters, E. F. M., & Martinez, F. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-01
- Volume
- 182
- Issue
- 5
- Pages
- 598-604
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1859222707
- Cited by
- 1,032
- References
- 7
- FWCI
- 68.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Han, M. K., Agusti, A., Calverley, P. M., Celli, B. R., Criner, G., Curtis, J. L., Fabbri, L. M., Goldin, J. G., Jones, P. W., MacNee, W., Make, B. J., Rabe, K. F., Rennard, S. I., Sciurba, F. C., Silverman, E. K., Vestbo, J., Washko, G. R., Wouters, E. F. M., & Martinez, F. J. (2010). Chronic Obstructive Pulmonary Disease Phenotypes: The Future of COPD. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200912-1843cc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
