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Cited by 252Asthma and respiratory diseasesAntifungal resistance and susceptibilityOccupational exposure and asthma

The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.

IgE Sensitization to Aspergillus fumigatus Is Associated with Reduced Lung Function in Asthma

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Fairs, Abbie, Agbetile, Joshua, Hargadon, Beverley, Bourne, Michelle, Monteiro, William R., Brightling, Christopher E., Bradding, Peter, Green, Ruth H., Mutalithas, Kugathasan, Desai, Dhananjay, Pavord, Ian D., Wardlaw, Andrew J., Pashley, Catherine H.·2010·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/rccm.201001-0087ocPMC PMC3029929
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Abstract

RATIONALE: The importance of Aspergillus fumigatus sensitization and colonization of the airways in patients with asthma is unclear. OBJECTIVES: To define the relationship between the clinical and laboratory features of A. fumigatus-associated asthma. METHODS: We studied 79 patients with asthma (89% classed as GINA 4 or 5) classified into 3 groups according to A. fumigatus sensitization: (1) IgE-sensitized (immediate cutaneous reactivity > 3 mm and/or IgE > 0.35 kU/L); (2) IgG-only-sensitized (IgG > 40 mg/L); and (3) nonsensitized. These were compared with 14 healthy control subjects. Sputum culture was focused toward detection of A. fumigatus and compared with clinical assessment data. MEASUREMENTS AND MAIN RESULTS: A. fumigatus was cultured from 63% of IgE-sensitized patients with asthma (n = 40), 39% of IgG-only-sensitized patients with asthma (n = 13), 31% of nonsensitized patients with asthma (n = 26) and 7% of healthy control subjects (n = 14). Patients sensitized to A. fumigatus compared with nonsensitized patients with asthma had lower lung function (postbronchodilator FEV₁ % predicted, mean [SEM]: 68 [±5]% versus 88 [±5]%; P < 0.05), more bronchiectasis (68% versus 35%; P < 0.05), and more sputum neutrophils (median [interquartile range]: 80.9 [50.1-94.1]% versus 49.5 [21.2-71.4]%; P < 0.01). In a multilinear regression model, A. fumigatus-IgE sensitization and sputum neutrophil differential cell count were important predictors of lung function (P = 0.016), supported by culture of A. fumigatus (P = 0.046) and eosinophil differential cell count (P = 0.024). CONCLUSIONS: A. fumigatus detection in sputum is associated with A. fumigatus-IgE sensitization, neutrophilic airway inflammation, and reduced lung function. This supports the concept that development of fixed airflow obstruction in asthma is consequent upon the damaging effects of airway colonization with A. fumigatus.

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Metadata

Authors
Fairs, A., Agbetile, J., Hargadon, B., Bourne, M., Monteiro, W. R., Brightling, C. E., Bradding, P., Green, R. H., Mutalithas, K., Desai, D., Pavord, I. D., Wardlaw, A. J., & Pashley, C. H.
Affiliations
University of Leicester (GB)
ORCID
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
2010-12-01
Volume
182
Issue
11
Pages
1362-1368
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/rccm.201001-0087oc
PMC
PMC3029929
OpenAlex
W2034519404
Cited by
252
References
39
Citations by year
2026: 9 · 2025: 7 · 2024: 14 · 2023: 10 · 2022: 9 · 2021: 17 · 2020: 26 · 2019: 20 · 2018: 18 · 2017: 16 · 2016: 10 · 2015: 15 · 2014: 15 · 2013: 19 · 2012: 28
FWCI
14.30
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • American Journal of Respiratory and Critical Care Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Leicester Research Archive (University of Leicester) (submittedVersion)
Funders
  • Wellcome Trust (082265)
  • Midlands Asthma and Allergy Research Association
  • European Regional Development Fund
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords
Aspergillus fumigatus, asthma, lung function, bronchiectasis, sputum neutrophils, eosinophils, airway colonization, IgE sensitization, IgG sensitization, FEV1, sputum culture, allergic asthma, non-allergic asthma, airway inflammation, bronchodilator response, eosinophilic asthma
MeSH terms
Adult, Aspergillus fumigatus, Asthma, Bronchiectasis, Female, Forced Expiratory Volume, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Lung, Male, Middle Aged, Neutrophils, Respiratory Function Tests, Severity of Illness Index, Sputum, Cohort Studies

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