Cited by 616Respiratory Support and MechanismsIntensive Care Unit Cognitive DisordersNosocomial Infections in ICU

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Chronic Critical Illness

Open access

Nelson, Judith E., Cox, Christopher E., Hope, Aluko A., Carson, Shannon S.·2010·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201002-0210ciPMC PMC2937238

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Abstract

Although advances in intensive care have enabled more patients to survive an acute critical illness, they also have created a large and growing population of chronically critically ill patients with prolonged dependence on mechanical ventilation and other intensive care therapies. Chronic critical illness is a devastating condition: mortality exceeds that for most malignancies, and functional dependence persists for most survivors. Costs of treating the chronically critically ill in the United States already exceed $20 billion and are increasing. In this article, we describe the constellation of clinical features that characterize chronic critical illness. We discuss the outcomes of this condition including ventilator liberation, mortality, and physical and cognitive function, noting that comparisons among cohorts are complicated by variation in defining criteria and care settings. We also address burdens for families of the chronically critically ill and the difficulties they face in decision-making about continuation of intensive therapies. Epidemiology and resource utilization issues are reviewed to highlight the impact of chronic critical illness on our health care system. Finally, we summarize the best available evidence for managing chronic critical illness, including ventilator weaning, nutritional support, rehabilitation, and palliative care, and emphasize the importance of efforts to prevent the transition from acute to chronic critical illness. As steps forward for the field, we suggest a specific definition of chronic critical illness, advocate for the creation of a research network encompassing a broad range of venues for care, and highlight areas for future study of the comparative effectiveness of different treatment venues and approaches.

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An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU
Pronovost, P., Needham, D., Berenholtz, S., Sinopoli, D., Chu, H., Cosgrove, S., Sexton, B., Hyzy, R., Welsh, R., Roth, G., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061115 · Cited by 4,387
A Controlled Trial to Improve Care for Seriously III Hospitalized Patients
Connors, A. F. (1995) · JAMA · doi:10.1001/jama.274.20.1591 · Cited by 3,451
Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial
Schweickert, W. D., Pohlman, M. C., Pohlman, A. S., Nigos, C., Pawlik, A. J., Esbrook, C. L., Spears, L., Miller, M., Franczyk, M., Deprizio, D., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60658-9 · Cited by 3,339
Physician Staffing Patterns and Clinical Outcomes in Critically Ill Patients
Pronovost, P. J., Angus, D. C., Dorman, T., Robinson, K. A., Dremsizov, T. T., & Young, T. (2002) · JAMA · doi:10.1001/jama.288.17.2151 · Cited by 1,506
Effect on the Duration of Mechanical Ventilation of Identifying Patients Capable of Breathing Spontaneously
Ely, E. W., Baker, A. M., Dunagan, D. P., Burke, H. L., Smith, A. C., Kelly, P. T., Johnson, M. M., Browder, R. W., Bowton, D. L., & Haponik, E. F. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612193352502 · Cited by 1,341
A communication strategy and brochure for relatives of patients dying in the ICU.
Lautrette, A., Darmon, M., Megarbane, B., Joly, L. M., Chevret, S., Adrie, C., Barnoud, D., Bleichner, G., Bruel, C., Choukroun, G., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063446 · Cited by 1,279 · cited 1×
“A new brochure about chronic critical illness is available as an adjunct to direct clinician counseling for education of patients and families (74); the value of printed informational materials for this purpose has been shown in randomized, controlled trials (75, 76).”
Background
Evidence-Based Guidelines for Weaning and Discontinuing Ventilatory Support
MacIntyre, N. R. (2001) · CHEST Journal · doi:10.1378/chest.120.6_suppl.375s · Cited by 1,245
Lorazepam Is an Independent Risk Factor for Transitioning to Delirium in Intensive Care Unit Patients
Pandharipande, P. P., Shintani, A., Peterson, J. F., Pun, B. T., Wilkinson, G. R., Dittus, R. S., Bernard, G. R., & Ely, E. W. (2005) · Anesthesiology · doi:10.1097/00000542-200601000-00005 · Cited by 1,231
EFFECT ON THE DURATION OF MECHANICAL VENTILATION OF IDENTIFYING PATIENTS CAPABLE OF BREATHING SPONTANEOUSLY
Esley, E. W., Ly, E., Aker, M., Unagan, D. O. P. D., Urke, L. B., Mith, C. S., Atrick, P., Elly, T. K., Argaret, M., Ohnson, M. J., et al. (1996) · Cited by 950
Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilation
Griffiths, J., Barber, V. S., Morgan, L., & Young, D. (2005) · BMJ · doi:10.1136/bmj.38467.485671.e0 · Cited by 643

Show all 78 references

Research works printed but not linked: 74

1985, Respir Care, 339
2005, Chest, 3937
2005, Chest, 507
2004, Crit Care Med, 61
1992, Chest, 211
2006, Nutr Clin Pract, 587
1997, J Clin Endocrinol Metab, 590
1997, Clin Endocrinol (Oxf), 599
2002, Crit Care Clin, 529
2007, Chest, 85
2006, Arch Intern Med, 1993
2004, Am J Surg, 18
2004, Crit Care Med, 1527
2004, Chest, 220
1996, Chest, 469
1989, Am Rev Respir Dis, S14
2009, Health Serv Outcomes Res Methodol, 117
2004, Crit Care Med, 2219
2007, Chest, 76
2007, Arch Intern Med, 2509
2005, Am Surg, 123
2000, Chest, 761
2006, Crit Care, R89
2007, Crit Care, R9
2008, Crit Care Med, 2061
2007, Crit Care Med, 2491
2001, Chest, 375S
2003, Chest, 1892
2007, Crit Care Med, 1918
2002, Crit Care Med, 2655
1999, Am J Respir Crit Care Med, 1568
2001, Chest, 1278
2000, Crit Care Med, 19
2003, Crit Care Med, 1373
2009, Crit Care, 118
2007, Am J Respir Crit Care Med, 167
2003, Chest, 1073
2010, Chest, 88
2009, Crit Care Med, 2888
2002, Am J Crit Care, 459
2003, Chest, 1039
2001, Chest, 928
2002, Intensive Care Med, 908
2008, Crit Care Med, 1451
2006, J Intensive Care Med, 173
2000, Chest, 1100
2004, Crit Care Med, 1254
1997, Chest, 1654
2001, Chest, 236
2007, Respir Care, 159
2002, Crit Care Clin, 493
2003, Intensive Care Med, 845
2001, Clin Nutr, 535
2009, Lancet, 1874
2005, Crit Care Med, 2527
2009, Crit Care Med, 177
2006, Anesthesiology, 21
2010, Crit Care Med, 428
1995, Mayo Clin Proc, 595
1995, Nurs Res, 324
2003, Crit Care Med, 2752
2005, BMJ, 1243
2005, Crit Care Med, 2513
2002, JAMA, 2151
1996, JAMA, 322
1996, N Engl J Med, 1864
2007, Crit Care Med, 365
2006, Crit Care Med, 1326
2006, N Engl J Med, 2725
2009, Crit Care Med, 919
1995, JAMA, 1591
2007, N Engl J Med, 469
2002, Am J Respir Crit Care Med, 438
2010, Intensive Care Med, 8

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King, D., Hussein, E., Shochet, G. E., & Bar‐Lavie, Y. (2020) · American Journal of Critical Care · doi:10.4037/ajcc2020934 · Cited by 11
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Ibrahim, S. G., Silva, J. M., Borges, L. G., Savi, A., Forgiarini, L. A., & Teixeira, C. (2012) · Revista Brasileira de Terapia Intensiva · doi:10.1590/s0103-507x2012000200012 · Cited by 11
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Bugedo, G. J., Egal, M., & Bakker, J. (2016) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.03.60 · Cited by 11
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Jo, M., Song, M., Riper, M. L. V., Yoo, Y., Knafl, G. J., & Beeber, L. S. (2017) · Heart & Lung · doi:10.1016/j.hrtlng.2017.08.002 · Cited by 9
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Authors: Nelson, J. E., Cox, C. E., Hope, A. A., & Carson, S. S.
Affiliations: Mount Sinai Hospital (US)
Duke University (US)
Icahn School of Medicine at Mount Sinai (US)
University of North Carolina at Chapel Hill (US)
ORCID: Nelson, Judith E.
Cox, Christopher E.
Hope, Aluko A.
Carson, Shannon S.
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2010-08
Volume: 182
Issue: 4
Pages: 446-454
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201002-0210ci
PMC: PMC2937238
OpenAlex: W2110115774
Cited by: 616
References: 78
Citations by year: 2026: 33 · 2025: 36 · 2024: 37 · 2023: 40 · 2022: 43 · 2021: 48 · 2020: 52 · 2019: 51 · 2018: 35 · 2017: 49 · 2016: 45 · 2015: 43 · 2014: 27 · 2013: 26 · 2012: 27
FWCI: 4.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institute on Aging (AG034234)
National Heart, Lung, and Blood Institute
National Institute of Nursing Research (R01NR012413)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Keywords: chronic critical illness, prolonged mechanical ventilation, ventilator liberation, mortality, functional dependence, cognitive function, family burden, end-of-life decisions, health care costs, resource utilization (health care), nutritional support, rehabilitation, palliative care, research networks
MeSH terms: Chronic Disease, Critical Care, Humans, United States, Ventilator Weaning, Critical Illness, Cost of Illness, Nutritional Support

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