The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis
Open accessAbstract
RATIONALE: We previously reported outcome-associated decreases in muscle energetic status and mitochondrial dysfunction in septic patients with multiorgan failure. We postulate that survivors have a greater ability to maintain or recover normal mitochondrial functionality. OBJECTIVES: To determine whether mitochondrial biogenesis, the process promoting mitochondrial capacity, is affected in critically ill patients. METHODS: Muscle biopsies were taken from 16 critically ill patients recently admitted to intensive care (average 1-2 d) and from 10 healthy, age-matched patients undergoing elective hip surgery. MEASUREMENTS AND MAIN RESULTS: Survival, mitochondrial morphology, mitochondrial protein content and enzyme activity, mitochondrial biogenesis factor mRNA, microarray analysis, and phosphorylated (energy) metabolites were determined. Ten of 16 critically ill patients survived intensive care. Mitochondrial size increased with worsening outcome, suggestive of swelling. Respiratory protein subunits and transcripts were depleted in critically ill patients and to a greater extent in nonsurvivors. The mRNA content of peroxisome proliferator-activated receptor γ coactivator 1-α (transcriptional coactivator of mitochondrial biogenesis) was only elevated in survivors, as was the mitochondrial oxidative stress protein manganese superoxide dismutase. Eventual survivors demonstrated elevated muscle ATP and a decreased phosphocreatine/ATP ratio. CONCLUSIONS: Eventual survivors responded early to critical illness with mitochondrial biogenesis and antioxidant defense responses. These responses may partially counteract mitochondrial protein depletion, helping to maintain functionality and energetic status. Impaired responses, as suggested in nonsurvivors, could increase susceptibility to mitochondrial damage and cellular energetic failure or impede the ability to recover normal function. Clinical trial registered with clinical trials.gov (NCT00187824).
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Self-citationHIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
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ICU-Acquired Weakness and Recovery from Critical Illness
Kress, J. P., & Hall, J. B. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1209390 · Cited by 855
Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis
Cheng, S.-C., Scicluna, B. P., Arts, R. J. W., Gresnigt, M. S., Lachmandas, E., Giamarellos-Bourboulis, E. J., Kox, M., Manjeri, G. R., Wagenaars, J. A. L., Cremer, O. L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3398 · Cited by 637
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill
Friedrich, O., Reid, M. B., Van den Berghe, G., Vanhorebeek, I., Hermans, G., Rich, M. M., & Larsson, L. (2015) · Physiological Reviews · doi:10.1152/physrev.00028.2014 · Cited by 396
Antimicrobial-associated harm in critical care: a narrative review
Arulkumaran, N., Routledge, M., Schlebusch, S., Lipman, J., & Conway Morris, A. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05929-3 · Cited by 175
Ashmore, T., Fernandez, B. O., Branco‐Price, C., West, J. A., Cowburn, A. S., Heather, L. C., Griffin, J. L., Johnson, R. S., Feelisch, M., & Murray, A. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.275263 · Cited by 58
Metadata
- Authors
- Carré, J. E., Orban, J.-C., Re, L., Felsmann, K., Iffert, W., Bauer, M., Suliman, H. B., Piantadosi, C. A., Mayhew, T. M., Breen, P., Stotz, M., & Singer, M.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-09-15
- Volume
- 182
- Issue
- 6
- Pages
- 745-751
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2133037534
- Cited by
- 441
- References
- 52
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Carré, J. E., Orban, J.-C., Re, L., Felsmann, K., Iffert, W., Bauer, M., Suliman, H. B., Piantadosi, C. A., Mayhew, T. M., Breen, P., Stotz, M., & Singer, M. (2010). Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201003-0326oc
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