Cited by 161Influenza Virus Research StudiesRespiratory viral infections researchinterferon and immune responses

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

GM-CSF in the Lung Protects against Lethal Influenza Infection

Open access

Huang, Fang-Fang, Barnes, Peter F., Feng, Yan, Donis, Ruben, Chroneos, Zissis C., Idell, Steven, Allen, Timothy, Perez, Daniel R., Whitsett, Jeffrey A., Dunussi-Joannopoulos, Kyri, Shams, Homayoun·2011·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.201012-2036ocPMC PMC6938174

Open this paper in CoChat — free account

Abstract

RATIONALE: Alveolar macrophages contribute to host defenses against influenza in animal models. Enhancing alveolar macrophage function may contribute to protection against influenza. OBJECTIVES: To determine if increased expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) in the lung increases resistance to influenza. METHODS: Wild-type mice and transgenic mice that expressed GM-CSF in the lung were infected with influenza virus, and lung pathology, weight loss, and mortality were measured. We also administered GM-CSF to the lungs of wild-type mice that were infected with influenza virus. MEASUREMENTS AND MAIN RESULTS: Wild-type mice all died after infection with different strains of influenza virus, but all transgenic mice expressing GM-CSF in the lungs survived. The latter also had greatly reduced weight loss and lung injury, and showed histologic evidence of a rapid host inflammatory response that controlled infection. The resistance of transgenic mice to influenza was abrogated by elimination of alveolar phagocytes, but not by depletion of T cells, B cells, or neutrophils. Transgenic mice had far more alveolar macrophages than did wild-type mice, and they were more resistant to influenza-induced apoptosis. Delivery of intranasal GM-CSF to wild-type mice also conferred resistance to influenza. CONCLUSIONS: GM-CSF confers resistance to influenza by enhancing innate immune mechanisms that depend on alveolar macrophages. Pulmonary delivery of this cytokine has the potential to reduce the morbidity and mortality due to influenza virus.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1164/rccm.201012-2036oc

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Granulocyte–Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression: A Double-Blind, Randomized, Placebo-controlled Multicenter Trial
Meisel, C., Schefold, J. C., Pschowski, R., Baumann, T., Hetzger, K., Gregor, J. I., Weber‐Carstens, S., Hasper, D., Keh, D., Zuckermann, H., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200903-0363oc · Cited by 683
Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
Sun, J., Madan, R., Karp, C. L., & Braciale, T. J. (2009) · Nature Medicine · doi:10.1038/nm.1929 · Cited by 626
GM-CSF Regulates Alveolar Macrophage Differentiation and Innate Immunity in the Lung through PU.1
Shibata, Y., Berclaz, P., Chroneos, Z. C., Yoshida, M., Whitsett, J. A., & Trapnell, B. C. (2001) · Immunity · doi:10.1016/s1074-7613(01)00218-7 · Cited by 623
Self-citation
Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know
Shi, Y., Liu, C. H., Roberts, A. I., Das, J., Xu, G., Ren, G., Zhang, Y., Zhang, L., Yuan, Z., Tan, H. S., et al. (2006) · Cell Research · doi:10.1038/sj.cr.7310017 · Cited by 550
Pathogenicity of Influenza Viruses with Genes from the 1918 Pandemic Virus: Functional Roles of Alveolar Macrophages and Neutrophils in Limiting Virus Replication and Mortality in Mice
Tumpey, T. M., García‐Sastre, A., Taubenberger, J. K., Palese, P., Swayne, D. E., Pantin‐Jackwood, M. J., Schultz‐Cherry, S., Solórzano, A., van Rooijen, N., Katz, J. M., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14933-14944.2005 · Cited by 504
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
Snelgrove, R. J., Goulding, J., Didierlaurent, A. M., Lyonga, D., Vekaria, S., Edwards, L., Findlay, E. G., Sedgwick, J. D., Barclay, A. N., & Hussell, T. (2008) · Nature Immunology · doi:10.1038/ni.1637 · Cited by 454
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus
Baskin, C. R., Bielefeldt-Ohmann, H., Tumpey, T. M., Sabourin, P. J., Long, J. P., García-Sastre, A., Tolnay, A.-E., Albrecht, R., Pyles, J. A., Olson, P. H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813234106 · Cited by 361
Fc Receptor-Mediated Phagocytosis Makes a Significant Contribution to Clearance of Influenza Virus Infections
Huber, V. C., Lynch, J. M., Bucher, D. J., Le, J., & Metzger, D. W. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7381 · Cited by 320
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
Tyner, J. W., Uchida, O., Kajiwara, N., Kim, E. Y., Patel, A. C., O’Sullivan, M. P., Walter, M. J., Schwendener, R. A., Cook, D. N., Danoff, T. M., et al. (2005) · Nature Medicine · doi:10.1038/nm1303 · Cited by 299
Type I IFN Modulates Innate and Specific Antiviral Immunity
Durbin, J. E., Fernández-Sesma, A., Lee, C., Rao, T. D., Frey, A. B., Moran, T. M., Vukmanović, S., García‐Sastre, A., & Levy, D. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4220 · Cited by 286

Show all 51 references

Sorted by citations

Items 101–161 of 161

Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia
Yang, P., Wang, X., Wang, H., Xu, W., Wu, K., Go, X., Yin, Y., & Zhang, X. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13628 · Cited by 11
T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation
Cammann, C., Israel, N., Frentzel, S., Jeron, A., Topfstedt, E., Schüler, T., Simeoni, L., Zenker, M., Fehling, H. J., Schraven, B. L., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.958616 · Cited by 13
Divergent Mast Cell Responses Modulate Antiviral Immunity During Influenza Virus Infection
Murphy-Schafer, A. R., & Paust, S. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.580679 · Cited by 12
An overview of some potential immunotherapeutic options against COVID-19
Bayat, M., Asemani, Y., Mohammadi, M. R., Sanaei, M., Namvarpour, M., & Eftekhari, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107516 · Cited by 11
Restoring resident tissue macrophages to combat aging and cancer
Park, M. D., Yatim, N., Zhang, J., Cho, B. A., Yoo, S., Schaefer, M. M., Chowell, D., Puleston, D. J., & Mérad, M. (2025) · Nature Aging · doi:10.1038/s43587-025-00898-y · Cited by 14
RIG-I agonist SLR10 promotes macrophage M1 polarization during influenza virus infection
Wu, W., Zhang, W., Alexandar, J. S., Booth, J. L., Miller, C., Xu, C., & Metcalf, J. P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1177624 · Cited by 11
Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia
Todd, E. M., Ramani, R., Szasz, T. P., & Morley, S. C. (2019) · Science Advances · doi:10.1126/sciadv.aax3387 · Cited by 11
Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19
Potter, H., Boyd, T. D., Clarke, P., Pelak, V. S., & Tyler, K. L. (2020) · F1000Research · doi:10.12688/f1000research.23729.1 · Cited by 11
A prophylactic effect of aluminium-based adjuvants against respiratory viruses via priming local innate immunity
Wang, X., Yin, X., Zhang, B., Liu, C., Lin, Y., Huang, X., Li, Y., Shen, C., Zheng, W., Fu, G., et al. (2022) · Emerging Microbes & Infections · doi:10.1080/22221751.2022.2050951 · Cited by 10
Lung Immune Cell Niches and the Discovery of New Cell Subtypes
Shan, Q., Qiu, J., Dong, Z., Xu, X., Zhang, S., Ma, J., & Liu, S. (2024) · Advanced Science · doi:10.1002/advs.202405490 · Cited by 10
Evidence-Based Management of the Critically Ill Adult With SARS-CoV-2 Infection
Chivukula, R. R., Maley, J. H., Dudzinski, D. M., Hibbert, K. A., & Hardin, C. C. (2020) · Journal of Intensive Care Medicine · doi:10.1177/0885066620969132 · Cited by 10
Ex vivo cytokine production in peripheral blood mononuclear cells after their stimulation with ds RNA of natural origin
Veinalde, R., Petrovska, R., Brüvere, R., Feldmane, G., & Pjanova, D. (2013) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1143 · Cited by 10
The role of CCR1 and therapeutic effects of anti‐CCL3 antibody in herpes simplex virus‐induced Behçet's disease mouse model
Sayeed, H. M., Lee, E., Byun, H., & Sohn, S. (2019) · Immunology · doi:10.1111/imm.13102 · Cited by 10
Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages
Gravel, C., Muralidharan, A., Duran, A., Zetner, A., Pfeifle, A., Zhang, W., Hashem, A. M., Tamming, L. A., Farnsworth, A., Loemba, H., et al. (2021) · iScience · doi:10.1016/j.isci.2021.103328 · Cited by 10
The Immune Response to Respiratory Viruses: From Start to Memory
Reijnders, T. D. Y., Schuurman, A. R., & van der Poll, T. (2021) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0041-1736459 · Cited by 11
Low-Dose Lipopolysaccharide Protects from Lethal Paramyxovirus Infection in a Macrophage- and TLR4-Dependent Process
Resiliac, J., Rohlfing, M. M., Santoro, J. L., Hussain, S.-R. A., & Grayson, M. H. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200604 · Cited by 11
Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization
Loison, E., & Gougeon, M. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.29520 · Cited by 9
Intranasal application of polyethyleneimine suppresses influenza virus infection in mice
He, B., Fu, Y., Xia, S., Yu, F., Wang, Q., Lu, L., & Jiang, S. (2016) · Emerging Microbes & Infections · doi:10.1038/emi.2016.64 · Cited by 9
Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) Infection: Let the Virus Be Its Own Demise
Nemunaitis, J. J., Stanbery, L., & Senzer, N. N. (2020) · Future Virology · doi:10.2217/fvl-2020-0068 · Cited by 9
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy
Bouzeineddine, N. Z., Philippi, A., Gee, K., & Basta, S. (2024) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.12.002 · Cited by 8
The immunomodulatory effect of inhaled granulocyte-macrophage colony-stimulating factor in cystic fibrosis. A new treatment paradigm
Nepper-Christensen, S., Bay, C., & Heslet, L. (2012) · Journal of Inflammation Research · doi:10.2147/jir.s22986 · Cited by 8
Effect of AcHERV-GmCSF as an Influenza Virus Vaccine Adjuvant
Choi, H. J., Gwon, Y.-D., Jang, Y., Cho, Y., Heo, Y., Lee, H.-J., Kim, K. C., Choi, J., Lee, J., & Kim, Y. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129761 · Cited by 8
Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2
Xu, R., Hong, H. A., Khandaker, S., Baltazar, M., Allehyani, N., Beentjes, D., Prince, T., Ho, Y.-L. T., Nguyen, L. H., Hynes, D., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1501907 · Cited by 10
CD69 mediates the protective role of adipose tissue‐derived mesenchymal stem cells against Pseudomonas aeruginosa pulmonary infection
Jiang, Y., Li, F., Li, Y., Duan, J., Di, C., Zhu, Y., Zhao, J., Jia, X., & Qu, J. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.563 · Cited by 6
Evaluating the evidence for GM-CSF as a host-directed therapy in respiratory infections
David, C., Verney, C., Si‐Tahar, M., & Guillon, A. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156902 · Cited by 7
Promoting immune defensive responses of epithelial cells in airway disease
Parnham, M. J., Norris, V., & Kricker, J. A. (2025) · Frontiers in Allergy · doi:10.3389/falgy.2025.1697194 · Cited by 6
Low concentrations of recombinant granulocyte macrophage-colony stimulating factor derived from Chinese hamster ovary cells augments long-term bioactivity with delayed clearance in vitro
Hashimoto, A., Tanaka, T., Itoh, Y., Yamagata, A., Kitamura, N., Tazawa, R., Nakagaki, K., & Nakata, K. (2014) · Cytokine · doi:10.1016/j.cyto.2014.03.009 · Cited by 6
SOCS3-deficient lung epithelial cells uptaking neutrophil-derived SOCS3 worsens lung influenza infection
Li, L., Wu, H., Li, Q., Chen, J., Xu, K., Xu, J., & Su, X. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.06.022 · Cited by 6
Alveolar macrophage-derived TGF-β promotes acute lung injury recovery by regulating inflammatory monocyte-derived macrophages
Hou, F., Xiao, J., Wang, H., Xiao, K., Yang, W., Zhao, D., Liu, D., Xie, L., & Tang, L. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.10.075 · Cited by 5
Antimicrobial immunotherapeutics: past, present and future
Mercer, D. K., Francis, M.-L. R., & Fraser-Pitt, D. J. (2021) · Emerging Topics in Life Sciences · doi:10.1042/etls20200348 · Cited by 5
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages
Yau, E., Chen, Y., Song, C., Webb, J., Carillo, M., Kawasawa, Y. I., Tang, Z., Takahashi, Y., Umstead, T. M., Dovat, S., et al. (2021) · Immunobiology · doi:10.1016/j.imbio.2021.152150 · Cited by 6
Self-citation
GM-CSF and Influenza: Will Saving Mice Help Humans?
WATERER, G. W. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201105-0833ed · Cited by 5
GM-CSF: a double dose of protection during pneumonia
Quinton, L. J. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00022.2012 · Cited by 5
Alternaria alternata Accelerates Loss of Alveolar Macrophages and Promotes Lethal Influenza A Infection
Percopo, C. M., Ma, M., Mai, E., Redes, J. L., Kraemer, L. S., Minai, M., Moore, I. N., Druey, K. M., & Rosenberg, H. F. (2020) · Viruses · doi:10.3390/v12090946 · Cited by 5
A toxicology study of Csf2ra complementation and pulmonary macrophage transplantation therapy of hereditary PAP in mice
Arumugam, P. I., Carey, B. C., Wikenheiser‐Brokamp, K. A., Krischer, J. P., Wessendarp, M., Shima, K., Chalk, C., Stock, J., Ma, Y., Black, D., et al. (2024) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2024.101213 · Cited by 4
Pulmonary Immunology of Infectious Disease
Burleson, G. R., Burleson, S. C. M., & BURLESON, F. G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-404577-4.00030-8 · Cited by 4
Immune Response after a Single Intravenous Peramivir Administration in Children with Influenza
Sato, M., Hashimoto, K., Kawasaki, Y., & Hosoya, M. (2017) · Antiviral Therapy · doi:10.3851/imp3222 · Cited by 4
Injury and Repair
Zemans, R. L., & Downey, G. P. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00015-4 · Cited by 4
Early treatment with inhaled GM-CSF improves oxygenation and anti-viral immunity in COVID-19 induced lung injury – a randomized clinical trialPreprint
Bosteels, C., Damme, K. F. A. V., Leeuw, E. D., Declercq, J., Maes, B., Bosteels, V., Hoste, L., Naesens, L., Debeuf, N., Deckers, J., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-959220/v1 · Cited by 3
Inhaled GM-CSF administered during ongoing pneumovirus infection alters myeloid and CD8 T cell immunity without affecting disease outcome
Debeuf, N., Deckers, J., Lameire, S., Bosteels, C., Hammad, H., & Lambrecht, B. N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1439789 · Cited by 2
GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during Legionella infection
Marrero, V. R. V., Dresler, M., Haggadone, M. D., Lu, A., & Shin, S. (2025) · Infection and Immunity · doi:10.1128/iai.00565-24 · Cited by 2
Update in Respiratory Infections 2011
Wunderink, R. G., & Niederman, M. S. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0540up · Cited by 2
Neue pathogenetische Konzepte und pharmakologische Studien zur adjuvanten Therapie bei schwerer Pneumonie
Lienau, J., Müller-Redetzky, H., Suttorp, N., & Witzenrath, M. (2015) · Pneumologie · doi:10.1055/s-0035-1563788 · Cited by 2
Critical insights into the pathogenesis of clinical isolates of pandemic influenza A(H1N1) 2009 virus in mouse and ferret models.
Camp, J. V. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2079 · Cited by 1
Decoding Cell-Cell Communications in Alveolar during Infection: Metabolic Control
Jiang, S. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.10.006 · Cited by 1
Lungs—Inflammatory and respiratory system
Faustino, L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821385-8.00009-3 · Cited by 1
The presence of SARS-CoV-2 in multiple clinical specimens of a fatal case of COVID-19: a case report
Sokolovska, L., Terentjeva, A., Čistjakovs, M., Nora-Krūkle, Z., Grāvelsiņa, S., Vilmane, A., Vecvagare, K., & Murovska, M. (2022) · Journal of Medical Case Reports · doi:10.1186/s13256-022-03706-y · Cited by 1
Pros and Cons for COVID-19 Vaccination and Boost of Young Adults in Light of Recent Literature
Nemunaitis, J. J., Lehmann, P., & Willey, J. C. (2022) · Medical Research Archives · doi:10.18103/mra.v10i8.2943 · Cited by 1
Global analysis of human SARS-CoV-2 infection and host-virus interactionPreprint
Ferrarini, M. G., Aguiar‐Pulido, V., Dawson, E. T., Guarracino, A., Gruber, A. J., Heumos, L., Kanitz, A., Lal, A., Pickett, B. E., Rebollo, R., et al. (2020) · doi:10.37044/osf.io/b4zkp
IFN-γ primes bone marrow neutrophils to acquire regulatory functions in severe viral respiratory infectionsPreprint
Creusat, F., Jouan, Y., Gonzalez, L., Barsac, E., Ilango, G., Lemoine, R., Soulard, D., Boisseau, C., Guillon, A., Lin, Q., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.23.568456 · Cited by 1
Epigenetic regulation of alveolar macrophage homeostasis by histone deacetylase 1 and 2Preprint
Lai, W., Luo, M., Wang, Y., Li, X., He, Z., Wu, L., & Wu, L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.06.590855 · Cited by 1
Reply to Roux and Ricard
Subramaniam, R., & Shams, H. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu243
Self-citation
Heterologous expression of biologically active chicken granulocyte-macrophage colony stimulating factor in Pichia pastoris
Ruan, W. (2012) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb11.3222
A Novel Mechanism of Enhanced Susceptibility to Bacterial Pneumonia in Influenza-infected Hosts
Ghoneim, H. E. (2013) · doi:10.21007/etd.cghs.2013.0108
Impact of obesity on immune responses to influenza virus infection
Kumar, A. A. (2016)
Current World Literature
(2012) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32835af239
Etude et origine des neutrophiles régulateurs dans l'infection pulmonaire
Creusat, F. (2019) · theses.fr (ABES) · doi:10.70675/7ea1f65czced3z48c9z9de0za4071fbb41a8
Inhaled granulocyte–macrophage colony-stimulating factor (molgramostim) as host-directed therapy for pneumonia-related acute respiratory distress syndrome: a multicentre, randomised, placebo-controlled phase 2a trial (GI-HOPE)
Herold, S., Welte, T., Zacharowski, K. D., Meybohm, P., Bauer, M., Wilhelm, J., Walmrath, H., Tello, K., Vadász, I., Hecker, M., et al. (2026) · ERJ Open Research · doi:10.1183/23120541.01795-2025
Infant-derived bifidobacterium can enhance the ability to respond to influenza virus infection by promoting type I interferon-mediated immunity
Shentu, J., Xie, Q., Yan, M., Wang, S., Sun, X., Zhang, C., Tian, P., Lv, X., Yang, B., Lu, W., et al. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109235
Homeostatic and inflammatory functions of pulmonary GM-CSF
Lechner, A., Gschwend, J., & Schneider, C. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.100380
The immune response in Influenza A-S. pneumoniae coinfection
Ellis, G. T. (2014) · UCL Discovery (University College London)

Authors: Huang, F.-F., Barnes, P. F., Feng, Y., Donis, R., Chroneos, Z. C., Idell, S., Allen, T., Perez, D. R., Whitsett, J. A., Dunussi-Joannopoulos, K., & Shams, H.
Affiliations: Center for Pulmonary and Infectious Disease Control
Centers for Disease Control and Prevention, Atlanta, Georgia
The University of Texas Health Science Center at Tyler (US)
University of Maryland, College Park (US)
Cincinnati Children's Hospital Medical Center (US)
Pfizer Research, Cambridge, Massachusetts
Corresponding author: Shams, Homayoun
ORCID: Feng, Yan
Chroneos, Zissis C.
Idell, Steven
Perez, Daniel R.
Whitsett, Jeffrey A.
Shams, Homayoun
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2011-07
Volume: 184
Issue: 2
Pages: 259-268
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.201012-2036oc
PMC: PMC6938174
OpenAlex: W2100796791
Cited by: 161
References: 51
Citations by year: 2026: 3 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 18 · 2020: 15 · 2019: 10 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 16 · 2014: 14 · 2013: 11 · 2012: 9
FWCI: 8.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Flight Attendant Medical Research Institute
Cain Foundation
National Heart, Lung, and Blood Institute (R01HL068127)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: GM-CSF, influenza virus, alveolar macrophages, innate immunity, lung protection, transgenic mice, lung injury, apoptosis, host defense
MeSH terms: Administration, Intranasal, Animals, Disease Models, Animal, Flow Cytometry, Lung, Mice, Inbred C57BL, Mice, Transgenic, Orthomyxoviridae Infections, Weight Loss, Granulocyte-Macrophage Colony-Stimulating Factor, Macrophages, Alveolar, Apoptosis, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

GM-CSF in the Lung Protects against Lethal Influenza Infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks