Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

Morris, Alison; Beck, James M.; Schloss, Patrick D.; Campbell, Thomas B.; Crothers, Kristina; Curtis, Jeffrey L.; Flores, Sonia C.; Fontenot, Andrew P.; Ghedin, Elodie; Huang, Laurence; Jablonski, Kathleen; Kleerup, Eric; Lynch, Susan V.; Sodergren, Erica; Twigg, Homer; Young, Vincent B.; Bassis, Christine M.; Venkataraman, Arvind; Schmidt, Thomas M.; Weinstock, George M.

doi:10.1164/rccm.201210-1913oc

Comparison of the Respiratory Microbiome in Healthy Nonsmokers and Smokers

Rationale Results from 16S rDNA-encoding gene sequence–based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome. Objectives To compare the microbiome of the upper and lower respiratory tract in healthy HIV-uninfected…