The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
IL-17 in Severe Asthma. Where Do We Stand?
Abstract
Asthma is a major chronic disease ranging from mild to severe refractory disease and is classified into various clinical phenotypes. Severe asthma is difficult to treat and frequently requires high doses of systemic steroids. In some cases, severe asthma even responds poorly to steroids. Several studies have suggested a central role of IL-17 (also called IL-17A) in severe asthma. Indeed, high levels of IL-17 are found in induced sputum and bronchial biopsies obtained from patients with severe asthma. The recent identification of a steroid-insensitive pathogenic Th17 pathway is therefore of major interest. In addition, IL-17A has been described in multiple aspects of asthma pathogenesis, including structural alterations of epithelial cells and smooth muscle contraction. In this perspective article, we frame the topic of IL-17A effects in severe asthma by reviewing updated information from human studies. We summarize and discuss the implications of IL-17 in the induction of neutrophilic airway inflammation, steroid insensitivity, the epithelial cell profile, and airway remodeling.
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Cites
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Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling
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IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
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Cited by
NF-kappaB Signaling in Chronic Inflammatory Airway Disease
Schuliga, M. (2015) · Biomolecules · doi:10.3390/biom5031266 · Cited by 428
Asthma in Children and Adults—What Are the Differences and What Can They Tell us About Asthma?
Trivedi, M., & Denton, E. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00256 · Cited by 283
Zhang, Z., Biagini Myers, J. M., Brandt, E. B., Ryan, P. H., Lindsey, M., Mintz-Cole, R. A., Reponen, T., Vesper, S. J., Forde, F., Ruff, B., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.031 · Cited by 98
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Guerra, E. S., Lee, C. K., Specht, C. A., Yadav, B., Huang, H., Akalin, A., Huh, J. R., Mueller, C., & Levitz, S. M. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006175 · Cited by 88
Metadata
- Authors
- Chesné, J., Braza, F., Mahay, G., Brouard, S., Aronica, M., & Magnan, A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-11-15
- Volume
- 190
- Issue
- 10
- Pages
- 1094-1101
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2111059503
- Cited by
- 377
- References
- 89
- FWCI
- 20.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chesné, J., Braza, F., Mahay, G., Brouard, S., Aronica, M., & Magnan, A. (2014). IL-17 in Severe Asthma. Where Do We Stand? American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201405-0859pp
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
