The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Timing of Low Tidal Volume Ventilation and Intensive Care Unit Mortality in Acute Respiratory Distress Syndrome. A Prospective Cohort Study
Open accessAbstract
RATIONALE: Reducing tidal volume decreases mortality in acute respiratory distress syndrome (ARDS). However, the effect of the timing of low tidal volume ventilation is not well understood. OBJECTIVES: To evaluate the association of intensive care unit (ICU) mortality with initial tidal volume and with tidal volume change over time. METHODS: Multivariable, time-varying Cox regression analysis of a multisite, prospective study of 482 patients with ARDS with 11,558 twice-daily tidal volume assessments (evaluated in milliliter per kilogram of predicted body weight [PBW]) and daily assessment of other mortality predictors. MEASUREMENTS AND MAIN RESULTS: An increase of 1 ml/kg PBW in initial tidal volume was associated with a 23% increase in ICU mortality risk (adjusted hazard ratio, 1.23; 95% confidence interval [CI], 1.06-1.44; P = 0.008). Moreover, a 1 ml/kg PBW increase in subsequent tidal volumes compared with the initial tidal volume was associated with a 15% increase in mortality risk (adjusted hazard ratio, 1.15; 95% CI, 1.02-1.29; P = 0.019). Compared with a prototypical patient receiving 8 days with a tidal volume of 6 ml/kg PBW, the absolute increase in ICU mortality (95% CI) of receiving 10 and 8 ml/kg PBW, respectively, across all 8 days was 7.2% (3.0-13.0%) and 2.7% (1.2-4.6%). In scenarios with variation in tidal volume over the 8-day period, mortality was higher when a larger volume was used earlier. CONCLUSIONS: Higher tidal volumes shortly after ARDS onset were associated with a greater risk of ICU mortality compared with subsequent tidal volumes. Timely recognition of ARDS and adherence to low tidal volume ventilation is important for reducing mortality. Clinical trial registered with www.clinicaltrials.gov (NCT 00300248).
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Cites
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Acute Respiratory Distress Syndrome: The Berlin Definition
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Cited by
Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., Gattinoni, L., van Haren, F., Larsson, A., McAuley, D. F., et al. (2016) · JAMA · doi:10.1001/jama.2016.0291 · Cited by 5,766
Fan, E., Del Sorbo, L., Goligher, E. C., Hodgson, C. L., Munshi, L., Walkey, A. J., Adhikari, N. K. J., Amato, M. B. P., Branson, R., Brower, R. G., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0548st · Cited by 1,630
Self-citationFormal guidelines: Management of acute respiratory distress syndrome.
Papazian, L., Aubron, C., Brochard, L., Chiche, J.-D., Combes, A., Dreyfuss, D., Forel, J.-M., Guérin, C., Jaber, S., Mekontso-Dessap, A., et al. (2019) · Annals of Intensive Care · doi:10.1186/s13613-019-0540-9 · Cited by 761
Acute respiratory distress syndrome
Sweeney, R. M., & McAuley, D. F. (2016) · The Lancet · doi:10.1016/s0140-6736(16)00578-x · Cited by 398
Mechanical Ventilation: State of the Art
Pham, T., Brochard, L. J., & Slutsky, A. S. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.05.004 · Cited by 377
Metadata
- Authors
- Needham, D. M., Yang, T., Dinglas, V. D., Mendez-Tellez, P. A., Shanholtz, C., Sevransky, J. E., Brower, R. G., Pronovost, P. J., & Colantuoni, E.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-01-15
- Volume
- 191
- Issue
- 2
- Pages
- 177-185
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2120144999
- Cited by
- 255
- References
- 38
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Needham, D. M., Yang, T., Dinglas, V. D., Mendez-Tellez, P. A., Shanholtz, C., Sevransky, J. E., Brower, R. G., Pronovost, P. J., & Colantuoni, E. (2015). Timing of Low Tidal Volume Ventilation and Intensive Care Unit Mortality in Acute Respiratory Distress Syndrome. A Prospective Cohort Study. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.201409-1598oc
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