The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias
Open accessAbstract
Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal interstitial lung disease (ILD) characterized by abnormal extracellular matrix (ECM) remodeling. We hypothesized that ECM remodeling might result in a plasma profile of proteins specific for IPF that could distinguish patients with IPF from other idiopathic ILDs. Objectives: To identify biomarkers that might assist in distinguishing IPF from non-IPF ILD. Methods: We developed a panel of 35 ECM, ECM-related, and lung-specific analytes measured in plasma from 86 patients with IPF (derivation cohort) and in 63 patients with IPF (validation cohort). Comparison groups included patients with rheumatoid arthritis–associated ILD (RA-ILD; n = 33), patients with alternative idiopathic ILDs (a-ILD; n = 41), and healthy control subjects (n = 127). Univariable and multivariable logistic regression models identified biomarkers that differentiated patients with IPF from those with a-ILD. Both continuous and diagnostic threshold versions of biomarkers were considered; thresholds were chosen to maximize summed diagnostic sensitivity and specificity in univariate receiver-operating characteristic curve analysis. A diagnostic score was created from the most promising analytes. Measurements and Main Results: Plasma surfactant protein (SP)-D > 31 ng/ml, matrix metalloproteinase (MMP)-7 > 1.75 ng/ml, and osteopontin > 6 ng/ml each significantly distinguished patients with IPF from patients with a-ILD, both individually and in a combined index. The odds ratio for IPF when at least one analyte in the index exceeded the threshold was 4.4 (95% confidence interval, 2.0–9.7; P = 0.0003). When at least two analytes were elevated, the odds ratio for IPF increased to 5.0 (95% confidence interval, 2.2–11.5; P = 0.0002). Conclusions: A biomarker index of SP-D, MMP-7, and osteopontin enhanced diagnostic accuracy in patients with IPF compared with those with non-IPF ILD. Our data suggest that this biomarker index may improve diagnostic confidence in IPF.
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“Another study showed that a panel including MMP7, surfactant protein D (SP-D) and osteopontin (OPN) enhanced diagnostic accuracy in IPF versus alternative idiopathic ILDs when plasma levels of at least one analyte in the panel exceeded a threshold (White et al., 2016).”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as White et al., 2016
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Cites
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186
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Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation
Booth, A. J., Hadley, R., Cornett, A. M., Dreffs, A. A., Matthes, S. A., Tsui, J. L., Weiss, K., Horowitz, J. C., Fiore, V. F., Barker, T. H., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0754oc · Cited by 665
Self-citationMMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
Rosas, I. O., Richards, T. J., Konishi, K., Zhang, Y., Gibson, K., Lokshin, A. E., Lindell, K. O., Cisneros, J., MacDonald, S. D., Pardo, A., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050093 · Cited by 582
Self-citationFibrotic extracellular matrix activates a profibrotic positive feedback loop
Parker, M. W., Rossi, D., Peterson, M., Smith, K. A., Sikström, K., White, E. S., Connett, J. E., Henke, C. A., Larsson, O. S., & Bitterman, P. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71386 · Cited by 572
Self-citationThe Two-Sample Trimmed t for Unequal Population Variances
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Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis
Pardo, A., Gibson, K. F., Cisneros, J., Richards, T. J., Yang, Y., Becerril, C., Yousem, S., Herrera, I., Ruiz, V., Selman, M., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020251 · Cited by 492
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Research works printed but not linked: 1
- Allam, 2008, Biomarkers in idiopathic pulmonary fibrosis: a lung tissue research consortium based study, Am J Respir Crit Care Med, 177, A46
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Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Raghu, G., Remy-Jardin, M., Myers, J. L., Richeldi, L., Ryerson, C. J., Lederer, D. J., Behr, J., Cottin, V., Danoff, S. K., Morell, F., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1255st · Cited by 4,103
Self-citationLederer, D. J., & Martinez, F. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1705751 · Cited by 2,056
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2018.12.052 · Cited by 1,261
“SASP factors that had been associated with frailty (IL6, MCP-1, activin A, apelin) [27–30] or had been reported to have prognostic or diagnostic potential in IPF (MMP1, MMP7, osteopontin) [31,32] were further validated by single target enzyme-linked immunosorbent assays (ELISA).”
BackgroundMartinez, F. J., Collard, H. R., Pardo, A., Raghu, G., Richeldi, L., Selman, M., Swigris, J. J., Taniguchi, H., & Wells, A. U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.74 · Cited by 1,388
Jenkins, G. R., Moore, B. B., Chambers, R. C., Eickelberg, O., Königshoff, M., Kolb, M. R. J., Laurent, G. J., Nanthakumar, C. B., Olman, M. A., Pardo, A., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0096st · Cited by 460
Self-citation
Metadata
- Authors
- White, E. S., Xia, M., Murray, S., Dyal, R., Flaherty, C. M., Flaherty, K. R., Moore, B. B., Cheng, L., Doyle, T. J., Villalba, J., Dellaripa, P. F., Rosas, I. O., Kurtis, J. D., & Martinez, F. J.
- Affiliations
- University of Michigan (US)
- Brown University (US)
- Division of Pulmonary and Critical Care and
- Brigham and Women's Hospital (US)
- Joan and Sanford Weill Department of Internal Medicine, Weill Cornell Medical College New York, New York
- Corresponding author
- White, Eric S.
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-11
- Volume
- 194
- Issue
- 10
- Pages
- 1242-1251
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC5114439
- OpenAlex
- W2346999058
- Cited by
- 180
- References
- 39
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 15 · 2023: 17 · 2022: 9 · 2021: 23 · 2020: 18 · 2019: 17 · 2018: 19 · 2017: 28 · 2016: 7
- FWCI
- 21.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01 HL085083, R01 HL109118, RC2 HL101740, K23 HL119558, P01HL114501, R01HL130974, HL115618)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Rheumatology › Systemic Sclerosis and Related Diseases
- Keywords
- idiopathic pulmonary fibrosis, idiopathic interstitial lung disease, plasma biomarkers, surfactant protein D, matrix metalloproteinase-7, osteopontin, extracellular matrix remodeling, rheumatoid arthritis-associated interstitial lung disease
- MeSH terms
- Diagnosis, Differential, Female, Humans, Male, Middle Aged, ROC Curve, Sensitivity and Specificity, Cohort Studies, Biomarkers, Matrix Metalloproteinase 7, Pulmonary Surfactant-Associated Protein D, Osteopontin, Idiopathic Interstitial Pneumonias, Idiopathic Pulmonary Fibrosis
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