Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma
Abstract
Rationale: Little is known regarding the impact of ambient ultrafine particles (UFPs; Objectives: To examine the association between prenatal and early postnatal life exposure to UFPs and development of childhood asthma. Methods: A total of 160,641 singleton live births occurring in the City of Toronto, Canada between April 1, 2006, and March 31, 2012, were identified from a birth registry. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using random effects Cox proportional hazards models, adjusting for personal- and neighborhood-level covariates. We investigated both single-pollutant and multipollutant models accounting for coexposures to particulate matter ≤2.5 μm in aerodynamic diameter (PM 2.5 ) and NO 2 . Measurements and Main Results: We identified 27,062 children with incident asthma diagnosis during the follow-up. In adjusted models, second-trimester exposure to UFPs (hazard ratio per interquartile range increase, 1.09; 95% confidence interval, 1.06-1.12) was associated with asthma incidence. In models additionally adjusted for PM 2.5 and nitrogen dioxide, UFPs exposure during the second trimester of pregnancy remained positively associated with childhood asthma incidence (hazard ratio per interquartile range increase, 1.05; 95% confidence interval, 1.01-1.09). Conclusions: This is the first study to evaluate the association between perinatal exposure to UFPs and the incidence of childhood asthma. Ex…
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In the first large-scale epidemiologic study, Lavigne et al. demonstrated in addition to PM2.5 and nitrate exposure, prenatal UFP exposure was independently associated with childhood asthma incidence.
“In the first large-scale epidemiologic study, Lavigne et al. [48] demonstrated in addition to PM2.5 and nitrate exposure, prenatal UFP exposure was independently associated with childhood asthma incidence.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [48]
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Johnson, N. M., Hoffmann, A. R., Behlen, J. C., Lau, C., Pendleton, D., Harvey, N., Shore, R., Li, Y., Chen, J., Tian, Y., et al. (2021) · Environmental Health and Preventive Medicine · doi:10.1186/s12199-021-00995-5 · Cited by 339 · see citing works
- Authors
- Lavigne, E., Donelle, J., Hatzopoulou, M., Van Ryswyk, K., van Donkelaar, A., Martin, R. V., Chen, H., Stieb, D. M., Gasparrini, A., Crighton, E., Yasseen, A. S., Burnett, R. T., Walker, M., & Weichenthal, S.
- Affiliations
- Air Health Science Division and
- Institute for Clinical Evaluative Sciences (CA)
- Department of Civil Engineering and
- Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada
- Smithsonian Institution (US)
- Health Canada (CA)
- London School of Hygiene & Tropical Medicine (GB)
- BORN Ontario (CA)
- University of Ottawa (CA)
- McGill University (CA)
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-06
- Volume
- 199
- Issue
- 12
- Pages
- 1487-1495
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2917538622
- Cited by
- 92
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 16 · 2023: 6 · 2022: 13 · 2021: 21 · 2020: 15 · 2019: 10
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Funders
- Medical Research Council (MR/R013349/1)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- ultrafine particles, childhood asthma, prenatal exposure, PM2.5, nitrogen dioxide, asthma incidence, lung development, spatiotemporal variation, birth registry
- MeSH terms
- Air Pollutants, Asthma, Canada, Child, Child, Preschool, Environmental Exposure, Female, Humans, Infant, Infant, Newborn, Male, Pregnancy, Cohort Studies, Incidence, Maternal Exposure, Particulate Matter, Spatio-Temporal Analysis
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