Prenatal Ambient Ultrafine Particle Exposure and Childhood Asthma in the Northeastern United States
Open accessAbstract
Rationale: Ambient ultrafine particles (UFPs; with an aerodynamic diameter Objectives: We used daily UFP exposure estimates to identify windows of susceptibility of prenatal UFP exposure related to asthma in children, accounting for sex-specific effects. Methods: Analyses included 376 mother-child dyads followed since pregnancy. Daily UFP exposure during pregnancy was estimated by using a spatiotemporally resolved particle number concentration prediction model. Bayesian distributed lag interaction models were used to identify windows of susceptibility for UFP exposure and examine whether effect estimates varied by sex. Incident asthma was determined at the first report of asthma (3.6 ± 3.2 yr). Covariates included maternal age, education, race, and obesity; child sex; nitrogen dioxide (NO 2 ) and temperature averaged over gestation; and postnatal UFP exposure. Measurements and Main Results: Women were 37.8% Black and 43.9% Hispanic, with 52.9% reporting having an education at the high school level or lower; 18.4% of children developed asthma. The cumulative odds ratio (95% confidence interval) for incident asthma per doubling of the UFP exposure concentration across pregnancy was 4.28 (1.41-15.7), impacting males and females similarly. Bayesian distributed lag interaction models indicated sex differences in the windows of susceptibility, with the highest risk of asthma seen in females exposed to higher UFP concentrations during late pregnancy. Conclusions: Prenatal UFP exposu…
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Wright et al. also observed prenatal UFP exposure was associated with asthma development in children in the Northeastern USA, independent of NO2 and temperature.
“Wright et al. [49] also observed prenatal UFP exposure was associated with asthma development in children in the Northeastern USA, independent of NO2 and temperature.”
From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [49]
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- Authors
- Wright, R. J., Hsu, H.-H. L., Chiu, Y.-H. M., Coull, B. A., Simon, M. C., Hudda, N., Schwartz, J., Kloog, I., & Durant, J. L.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Department of Environmental Medicine and Public Health and
- Department of Biostatistics and
- Volpe National Transportation Systems Center (US)
- Tufts University (US)
- Harvard University (US)
- Corresponding author
- Wright, Rosalind J.
- ORCID
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-10-01
- Volume
- 204
- Issue
- 7
- Pages
- 788-796
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC8528517
- OpenAlex
- W3161667109
- Cited by
- 53
- References
- 51
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 10 · 2023: 9 · 2022: 11 · 2021: 6
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR001433, UL1TR004419, UH3OD023337)
- National Institute on Aging (P01AG023394)
- National Heart, Lung, and Blood Institute (R01HL095606, R01HL114396, R01HL080674, P50HL105185, U01HL072494)
- National Institute of Environmental Health Sciences (R01ES030302, P30ES000002, R01ES010932, P30ES023515)
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities (R01MD006086)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
- Keywords
- ultrafine particles, prenatal exposure, childhood asthma, air pollution, windows of susceptibility, sex differences, maternal exposure, particle number concentration, nitrogen dioxide, ambient temperature, children's respiratory health, northeastern United States
- MeSH terms
- Adolescent, Adult, Air Pollutants, Air Pollution, Asthma, Bayes Theorem, Child, Child, Preschool, Female, Humans, Infant, Male, New England, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Sex Factors, Incidence, Logistic Models, Odds Ratio, Maternal Exposure, Particulate Matter, Young Adult
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