The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Cell number and distribution in human and rat airways.
Abstract
Morphometric procedures were used to determine the number of cells, cell volume, cell diameter, and surface areas of the airways in human and rat lungs. Nuclear sizes of epithelial cells from human bronchi were significantly larger than other lung cell nuclei. The average volume of human ciliated cell nuclei was 310 +/- 30 microns 3 and 167 +/- 12 microns 3 in bronchi and bronchioles, respectively. The smaller nuclei of human bronchioles were comparable to those of alveolar cells. In the pseudostratified epithelium of human bronchi, basal cells had a large surface area in contact with the basement membrane (51.3 +/- 4.6 microns 2 per cell) when compared with ciliated (1.1 +/- 0.1 microns 2), goblet (7.6 +/- 1.2 microns 2), or other secretory cells (12.0 +/- 2.1 microns 2). In the first four airway generations distal to the trachea, basal cells account for 30% of the cells in human airway epithelium and 2% of the cells in rat airway epithelium. Total airway surface area from trachea to bronchioles was 2,471 +/- 320 and 27.2 +/- 1.7 cm2 in human and rat lungs, respectively. These direct measurements of airway surface area are less than half of the estimates based on current lung models. The total number of airway epithelial cells were 10.5 x 10(9) for human and 0.05 x 10(9) for rat lungs. For both species, there were 18 times more alveolar cells than bronchial epithelial cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multiple Range and Multiple F Tests
Duncan, D. B. (1955) · Biometrics · doi:10.2307/3001478 · Cited by 23,217
Weibel, E. R. (1963) · Springer eBooks · doi:10.1007/978-3-642-87553-3 · Cited by 3,353
A simple method for volumetry of organs in quantitative stereology.
Scherle, W. F. (1970) · PubMed · Cited by 1,047
Bates, D. V., Fish, B., Hatch, T. F., Mercer, T. T., & Morrow, P. E. (1966) · PubMed · Cited by 771
Cell number and cell characteristics of the normal human lung.
Crapo, J. D., Barry, B. E., Gehr, P., Bachofen, M., & Weibel, E. R. (1982) · PubMed · doi:10.1164/arrd.1982.125.6.740 · Cited by 738
Self-citationModels of human lung airways and their application to inhaled particle deposition
Yeh, H.-C., & Schum, G. M. (1980) · Bulletin of Mathematical Biology · doi:10.1007/bf02460796 · Cited by 717
Allometric Relationships of Cell Numbers and Size in the Mammalian Lung
Stone, K. C., Mercer, R. R., Gehr, P., Stockstill, B., & Crapo, J. D. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/6.2.235 · Cited by 550
Self-citationMorphology of the bronchial tree in man.
Horsfield, K., & Cumming, G. (1968) · Journal of Applied Physiology · doi:10.1152/jappl.1968.24.3.373 · Cited by 487
Michel, R. P., & Cruz‐Orive, L. M. (1988) · Journal of Microscopy · doi:10.1111/j.1365-2818.1988.tb04603.x · Cited by 431
Bair, W. J. (1989) · Health Physics · doi:10.1097/00004032-198907001-00032 · Cited by 330
Cited by
An estimation of the number of cells in the human body
Bianconi, E., Piovesan, A., Facchin, F., Beraudi, A., Casadei, R., Frabetti, F., Vitale, L., Pelleri, M. C., Tassani, S., Piva, F., et al. (2013) · Annals of Human Biology · doi:10.3109/03014460.2013.807878 · Cited by 1,012
SARS-CoV-2 (COVID-19) by the numbers
Bar-On, Y. M., Flamholz, A., Phillips, R., & Milo, R. (2020) · eLife · doi:10.7554/elife.57309 · Cited by 962
Cilia and Mucociliary Clearance
Bustamante-Marin, X. M., & Ostrowski, L. E. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028241 · Cited by 830
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro
Benam, K. H., Villenave, R., Lucchesi, C., Varone, A., Hubeau, C., Lee, H.-H., Alves, S. E., Salmon, M., Ferrante, T. C., Weaver, J. C., et al. (2016) · Nature Methods · doi:10.1038/nmeth.3697 · Cited by 816
Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
Rock, J. R., Randell, S. H., & Hogan, B. L. M. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.006031 · Cited by 730
Metadata
- Authors
- Mercer, R. R., Russell, M. L., Roggli, V. L., & Crapo, J. D.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1994-06
- Volume
- 10
- Issue
- 6
- Pages
- 613-624
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2158899370
- Cited by
- 395
- References
- 23
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cell number and distribution in human and rat airways. https://app.cochat.ai/papers/10.1165/ajrcmb.10.6.8003339
- The paper
- Mercer, R. R., Russell, M. L., Roggli, V. L., & Crapo, J. D. (1994). Cell number and distribution in human and rat airways. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.10.6.8003339
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
