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Interleukin-17 Stimulates the Expression of Interleukin-8, Growth-Related Oncogene- α , and Granulocyte–Colony-Stimulating Factor by Human Airway Epithelial Cells
Abstract
Interleukin (IL)-17 is a recently discovered cytokine, which is proposed to play a role in neutrophilic airway inflammation via the release of proinflammatory cytokines and chemokines. To evaluate the role of IL-17 in inflammatory protein production from the airway epithelium, we have analyzed the effects of IL-17 on primary human bronchial epithelial cells (HBECs). Using gene arrays, changes in gene expression in response to IL-17 stimulation were investigated and only IL-8, growth-related oncogene (Gro)alpha, and granulocyte colony-stimulating factor (G-CSF) were found to be upregulated. Secretion of IL-8, Groalpha, and G-CSF in response to IL-17 was measured in HBEC cell culture supernatants by enzyme-linked immunosorbent assay. Upregulation of Groalpha, IL-8, and G-CSF was observed to be 8-, 5-, and 8-fold, respectively, after 48 h stimulation with IL-17. When tested at equivalent concentrations, IL-17 was found to be 2- to 3-fold more potent than tumor necrosis factor (TNF)-alpha in stimulating release of Groalpha and G-CSF from HBECs. In addition, IL-17 was found to synergistically enhance TNF-alpha-induced production of IL-8, Groalpha, and G-CSF. It is proposed that IL-17 may play an important role in neutrophil recruitment via stimulating the release of IL-8, Groalpha, and G-CSF from airway epithelial cells.
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Cites
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 2×
“Several studies have shown that IL-17 induces IL-6 release from multiple cell types including fibroblasts, stromal cells, and endothelial cells (8, 11 ).”
Cited by
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,372
Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03356.x · Cited by 762
Mediators of Chronic Obstructive Pulmonary Disease
Barnes, P. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.2 · Cited by 710
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
Cho, J. S., Pietras, E. M., Garcia, N. C., Ramos, R. I., Farzam, D. M., Monroe, H. R., Magorien, J. E., Blauvelt, A., Kolls, J. K., Cheung, A. L., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40891 · Cited by 658
The roles of IL‐17A in inflammatory immune responses and host defense against pathogens
Iwakura, Y., Nakae, S., Saijo, S., & Ishigame, H. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00699.x · Cited by 513
Metadata
- Authors
- Jones, C. E., & Chan, K.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-06-01
- Volume
- 26
- Issue
- 6
- Pages
- 748-753
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2072263302
- Cited by
- 289
- References
- 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Interleukin-17 Stimulates the Expression of Interleukin-8, Growth-Related Oncogene- α , and Granulocyte–Colony-Stimulating Factor by Human Airway Epithelial Cells. https://app.cochat.ai/papers/10.1165/ajrcmb.26.6.4757
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- Jones, C. E., & Chan, K. (2002). Interleukin-17 Stimulates the Expression of Interleukin-8, Growth-Related Oncogene- α , and Granulocyte–Colony-Stimulating Factor by Human Airway Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb.26.6.4757
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