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Properties and Function of Lysyl Oxidase
Abstract
Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.
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Tilakaratne, W. M., Klinikowski, M. F., Saku, T., Peters, T. J., & Warnakulasuriya, S. (2006) · Oral Oncology · doi:10.1016/j.oraloncology.2005.08.005 · Cited by 666
Lysyl oxidase: Properties, regulation and multiple functions in biology
Smith-Mungo, L. I., & Kagan, H. M. (1998) · Matrix Biology · doi:10.1016/s0945-053x(98)90012-9 · Cited by 578
Self-citationThe application of recombinant human collagen in tissue engineering
Yang, C., Hillas, P. J., B??ez, J. A., Nokelainen, M., Balan, J., Tang, J., Spiro, R., & Polarek, J. W. (2004) · BioDrugs · doi:10.2165/00063030-200418020-00004 · Cited by 385
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Metadata
- Authors
- Kagan, H. M., & Trackman, P. C.
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-09
- Volume
- 5
- Issue
- 3
- Pages
- 206-210
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- OpenAlex
- W2034356701
- Cited by
- 331
- References
- 0
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Properties and Function of Lysyl Oxidase. https://app.cochat.ai/papers/10.1165/ajrcmb/5.3.206
- The paper
- Kagan, H. M., & Trackman, P. C. (1991). Properties and Function of Lysyl Oxidase. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/ajrcmb/5.3.206
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
