The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Spectral Domain Optical Coherence Tomography in Mouse Models of Retinal Degeneration
Open accessAbstract
PURPOSE: Spectral domain optical coherence tomography (SD-OCT) allows cross-sectional visualization of retinal structures in vivo. Here, the authors report the efficacy of a commercially available SD-OCT device to study mouse models of retinal degeneration. METHODS: C57BL/6 and BALB/c wild-type mice and three different mouse models of hereditary retinal degeneration (Rho(-/-), rd1, RPE65(-/-)) were investigated using confocal scanning laser ophthalmoscopy (cSLO) for en face visualization and SD-OCT for cross-sectional imaging of retinal structures. Histology was performed to correlate structural findings in SD-OCT with light microscopic data. RESULTS: In C57BL/6 and BALB/c mice, cSLO and SD-OCT imaging provided structural details of frequently used control animals (central retinal thickness, CRT(C57BL/6) = 237 +/- 2 microm and CRT(BALB/c) = 211 +/- 10 microm). RPE65(-/-) mice at 11 months of age showed a significant reduction of retinal thickness (CRT(RPE65) = 193 +/- 2 microm) with thinning of the outer nuclear layer. Rho(-/-) mice at P28 demonstrated degenerative changes mainly in the outer retinal layers (CRT(Rho) = 193 +/- 2 microm). Examining rd1 animals before and after the onset of retinal degeneration allowed monitoring of disease progression (CRT(rd1 P11) = 246 +/- 4 microm, CRT(rd1 P28) = 143 +/- 4 microm). Correlation of CRT assessed by histology and SD-OCT was high (r(2) = 0.897). CONCLUSIONS: The authors demonstrated cross-sectional visualization of retinal structures in wild-type mice and mouse models for retinal degeneration in vivo using a commercially available SD-OCT device. This method will help to reduce numbers of animals needed per study by allowing longitudinal study designs and will facilitate characterization of disease dynamics and evaluation of putative therapeutic effects after experimental interventions.
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Cites
Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis
Maguire, A. M., Simonelli, F., Pierce, E. A., Pugh, E. N., Mingozzi, F., Bennicelli, J., Banfi, S., Marshall, K. A., Testa, F., Surace, E. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802315 · Cited by 2,145
Self-citationEffect of gene therapy on visual function in Leber’s congenital amaurosis
Bainbridge, J. W. B., Smith, A. J., Barker, S. S., Robbie, S., Henderson, R., Balaggan, K., Viswanathan, A., Holder, G. E., Stockman, A., Tyler, N., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802268 · Cited by 1,924
Mutations in RPE65 cause autosomal recessive childhood–onset severe retinal dystrophy
Gu, S.-M., Thompson, D. A., Srikumari, C. R. S., Lorenz, B., Finckh, U., Nicoletti, A., Murthy, K. R., Rathmann, M., Kumaramanickavel, G., Denton, M. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-194 · Cited by 663
Mutations in RPE65 cause Leber's congenital amaurosis
Marlhens, F., Bareil, C., Griffoin, J.-M., Zrenner, E., Amalric, P., Eliaou, C., Liu, S.-Y., Harris, E., Redmond, T. M., Arnaud, B., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-139 · Cited by 606
Self-citationCone Opsin Mislocalization in Rpe65−/−Mice: A Defect That Can Be Corrected by 11-cis Retinal
Rohrer, B., Lohr, H. R., Humphries, P., Redmond, T. M., Seeliger, M. W., & Crouch, R. K. (2005) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-0533 · Cited by 133
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Cited by
Optical Coherence Tomography: History, Current Status, and Laboratory Work
Gabriele, M. L., Wollstein, G., Ishikawa, H., Kagemann, L., Xu, J., Folio, L. S., & Schuman, J. S. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6312 · Cited by 310
Dev Borman, A., Ocaka, L. A., Mackay, D. S., Ripamonti, C., Henderson, R. H., Moradi, P., Hall, G., Black, G. C., Robson, A. G., Holder, G. E., et al. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-9548 · Cited by 44
QLT091001, a 9-cis-Retinal Analog, Is Well-Tolerated by Retinas of Mice with Impaired Visual Cycles
Maeda, T., Dong, Z., Jin, H., Sawada, O., Gao, S., Utkhede, D., Monk, W., Palczewska, G., & Palczewski, K. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.12-11152 · Cited by 41
Metadata
- Authors
- Huber, G., Beck, S. C., Grimm, C., Sahaboglu-Tekgoz, A., Paquet-Durand, F., Wenzel, A., Humphries, P., Redmond, T. M., Seeliger, M. W., & Fischer, M. D.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2009-12-01
- Volume
- 50
- Issue
- 12
- Pages
- 5888
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2081118860
- Cited by
- 199
- References
- 5
- FWCI
- 5.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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