One-Year Outcome of 49-Channel Suprachoroidal–Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa
Open accessAbstract
PURPOSE: To determine the feasibility of a 49-channel suprachoroidal-transretinal stimulation (STS) retinal prosthesis that was implanted for 1 year. METHODS: Three patients with advanced retinitis pigmentosa (RP) and with less than or equal to hand motion (HM) vision were studied. A 49-channel STS system was implanted in a scleral pocket, and the stability of the prosthesis, adverse events, and its efficacy were investigated. RESULTS: The electrode array was implanted in a scleral pocket located under the parafoveal area through a scleral incision at 14 mm in patient (Pt) 1, 16 mm in Pt 2, and 18 mm in Pt 3 from the sclerocorneal limbus. No complications occurred during surgery in all cases. During the follow-up period, iridocyclitis developed in Pt 2 and Pt 3, which was successfully treated with topical medications. The implanted devices continued functioning and elicited phosphenes in all cases. The results of localization tests (P < 0.05) and table tests (P < 0.05) were significantly better with the prosthesis turned on than turned off in Pt 3. The deviations of the walking tests were smaller with the prosthesis turned on than off in Pt 2 and Pt 3 at multiple times after the implantation. CONCLUSIONS: The 49-channel STS retinal prosthesis was able to elicit phosphenes in all patients with advanced RP for the entire 1-year experimental period without major complications. Better results on visual tasks were found in the eyes in which the electrode array was implanted closer to the fovea centralis.
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Studies on suprachoroidal devices have generally assessed patient autonomy, mobility, and object discrimination, rather than visual acuity.
“In comparison, studies on suprachoroidal devices25,36 have generally assessed patient autonomy, mobility, and object discrimination, rather than visual acuity.”
From Visual Prostheses in the Era of Artificial Intelligence Technology (2025) · cites this paper as [36]
Suprachoroidal prostheses have good mechanical stability without fixation with retinal tacks and, like epiretinal prostheses, good heat dissipation capacity and allow the insertion of large arrays.
“Like subretinal prostheses, they have good mechanical stability without fixation with retinal tacks [56,58] and, like epiretinal prostheses, they have good heat dissipation capacity and allow the insertion of large arrays [57].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [58]
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References 25 · Cited by 101
- Authors
- Fujikado, T., Kamei, M., Sakaguchi, H., Kanda, H., Endo, T., Hirota, M., Morimoto, T., Nishida, K., Kishima, H., Terasawa, Y., Oosawa, K., Ozawa, M., & Nishida, K.
- Affiliations
- The University of Osaka (JP)
- Nidek (Japan) (JP)
- Corresponding author
- Fujikado, Takashi
- ORCID
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2016-11-11
- Volume
- 57
- Issue
- 14
- Pages
- 6147
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2551557427
- Cited by
- 101
- References
- 25
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 15 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 17 · 2018: 8 · 2017: 7 · 2016: 1
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (26462684, 25293354, 15K16353)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- retinal prosthesis, retinitis pigmentosa, phosphenes, visual localization, walking performance, iridocyclitis
- MeSH terms
- Adult, Aged, Choroid, Electric Stimulation, Evoked Potentials, Visual, Feasibility Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pilot Projects, Prospective Studies, Retina, Retinitis Pigmentosa, Time Factors, Visual Acuity, Treatment Outcome, Visual Prosthesis
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